N'-(三苯甲基)-L-组氨酸合成路线 （共 10 条）
反应条件
piperidine in tetrahydrofuran 2 h;
参考文献
WO2012/136604 A1, ;
Page/Page column 42-43 ;
反应条件
1: 1.) triethylamine / 1.) dimethylformamide, chloroform, 30-35 deg C, 20 min; 2.) 1 h 2: methanol 3: conc. HCl / acetone / 5 °C 4: 2 M ammonia / 0.05 h View Scheme
参考文献
Chemistry of Natural Compounds, , vol. 18, # 3 p. 322 - 327
Khimiya Prirodnykh Soedinenii, , # 3 p. 349 - 354
反应条件
1: conc. HCl / acetone / 5 °C 2: 2 M ammonia / 0.05 h View Scheme
参考文献
Chemistry of Natural Compounds, , vol. 18, # 3 p. 322 - 327
Khimiya Prirodnykh Soedinenii, , # 3 p. 349 - 354
反应条件
ammonium hydroxide 0.05 h; Yield given;
参考文献
Chemistry of Natural Compounds, , vol. 18, # 3 p. 322 - 327
Khimiya Prirodnykh Soedinenii, , # 3 p. 349 - 354
反应条件
Yield given. Multistep reaction;
参考文献
Journal of Organic Chemistry, , vol. 47, # 7 p. 1324 - 1326
反应条件
Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Journal of Organic Chemistry, , vol. 47, # 7 p. 1324 - 1326
反应条件
potassium carbonate in isopropyl alcohol T=30 - 35°C; 0.666667 h;
参考文献
Pozdnev, V. F.
Chemistry of Natural Compounds, 1982 , vol. 18, # 3 p. 322 - 327
Khimiya Prirodnykh Soedinenii, 1982 , # 3 p. 349 - 354
反应条件
hydrogenchloride in water T=20°C; 0.5 h;
参考文献
Palladino, Pasquale; Stetsenko, Dmitry A.
Organic Letters, 2012 , vol. 14, # 24 p. 6346 - 6349
反应条件
1: N(im)-trityl-L-histidine With N,N-dicyclohexylamine in acetone T=20°C; 2: 1-[[(9H-fluoren-9-ylmethoxy)carbonyl]oxy]-2,5-pyrrolidinedione With sodium carbonate in water; acetonitrile T=0 - 20°C; pH=8; 3: With potassium hydrogensulfate in water; acetonitrile pH=2 - 3;
参考文献
Nowshuddin, Shaik; Rao; Reddy, A. Ram
Synthetic Communications, 2009 , vol. 39, # 11 p. 2022 - 2031
反应条件
sodium carbonate in 1,4-dioxane 1.) 1h, 0 deg C, 2.) 12h, room temperature;
参考文献
Barlos, Kleomenis; Mamos, Petros; Papaioannou, Dionysios; Patrianakou, Stella; Sanida, Chariklia; Schaefer, Wolfram
Liebigs Annalen der Chemie, 1987 , p. 1025 - 1030
