氧杂环丁烷-3-亚甲基乙酸乙酯合成路线 （共 9 条）
反应条件
in dichloromethane T=0 - 20°C; 1.5 h; Large scale;
参考文献
PFIZER LIMITED; BAGAL, Sharanjeet Kaur; KEMP, Mark Ian; MILLER, Duncan Charles; MURATA, Yoshihisa
Patent: WO2013/61205 A2, 2013 ;
Location in patent: Page/Page column 67 ;
参考文献
US2008/207573 A1, ;
Page/Page column 87-88 ;
反应条件
in ethanol; water 6 - 12 h; Heating / reflux;
参考文献
Myriad Genetics, Incorporated
Patent: US2008/207573 A1, 2008 ;
Location in patent: Page/Page column 87-88 ;
反应条件
potassium cyanide; 18-crown-6 ether in acetonitrile T=20°C; 20 h; Inert atmosphere;
参考文献
Wuitschik, Georg; Carreira, Erick M.; Wagner, Bjoern; Fischer, Holger; Parrilla, Isabelle; Schuler, Franz; Rogers-Evans, Mark; Mueller, Klaus
Journal of Medicinal Chemistry, 2010 , vol. 53, # 8 p. 3227 - 3246
反应条件
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 20 °C 1.2: 4 h / 20 °C 2.1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 0 - 20 °C 3.1: triethylamine / dichloromethane / 0 - 20 °C 4.1: triethylamine / acetonitrile / 12 h / Reflux 5.1: hydrogen / palladium(II) oxide hydrate / methanol / 20 °C View Scheme
参考文献
AMGEN INC.; ALLEN, Jennifer R.; CHEN, Jian J.; FROHN, Michael J.; HU, Essa; LIU, Qingyian; PICKRELL, Alexander J.; RUMFELT, Shannon; RZASA, Robert M.; ZHONG, Wenge
Patent: WO2011/143365 A1, 2011 ;
WO 2011/143365 A1
反应条件
[RhCl(η2:η2-cycloocta-1,5-diene)]2; water; potassium hydroxide in 1,4-dioxane T=20°C;
参考文献
Wuitschik, Georg; Carreira, Erick M.; Wagner, Bjoern; Fischer, Holger; Parrilla, Isabelle; Schuler, Franz; Rogers-Evans, Mark; Mueller, Klaus
Journal of Medicinal Chemistry, 2010 , vol. 53, # 8 p. 3227 - 3246
反应条件
ammonia in ethanol
T=100°C; 5 h; Sealed tube;
参考文献
PFIZER LIMITED; BAGAL, Sharanjeet Kaur; KEMP, Mark Ian; MILLER, Duncan Charles; MURATA, Yoshihisa
Patent: WO2013/61205 A2, 2013 ;
Location in patent: Page/Page column 63 ;
反应条件
potassium hydroxide; [RhCl(η2:η2-cycloocta-1,5-diene)]2 in 1,4-dioxane; water
T=20°C; 6 h;
参考文献
Wuitschik, Georg; Carreira, Erick M.; Wagner, Bjoern; Fischer, Holger; Parrilla, Isabelle; Schuler, Franz; Rogers-Evans, Mark; Mueller, Klaus
Journal of Medicinal Chemistry, 2010 , vol. 53, # 8 p. 3227 - 3246
反应条件
1.1: copper(l) iodide; chloro-trimethyl-silane / tetrahydrofuran / 0.25 h / 20 °C / |Inert atmosphere
1.2: 1.17 h / -15 - 25 °C
2.1: water; sodium hydroxide / methanol / 12 h / 40 °C
View Scheme
参考文献
GENENTECH,INC.; FORMA TM, LLC; YUEN, Po-Wai; BAIR, Kenneth, W.; BAUMEISTER, Timm, R.; DRAGOVICH, Peter; LIU, Xiongcai; PATEL, Snahel; ZAK, Mark; ZHAO, Guiling; ZHANG, Yamin; ZHENG, Xiaozhang
Patent: WO2013/127269 A1, 2013 ;
