N-甲氧基-N-甲基乙酰胺合成路线 （共 87 条）
参考文献
Berenguer, Ramon; Cavero, Marta; Garcia, Jordi; Munoz, Montse
Tetrahedron Letters, 1998 , vol. 39, # 15 p. 2183 - 2186
反应条件
1: 2,6-di-fluoro-pyridine With n-butyllithium in tetrahydrofuran; hexane T=-70 - -60°C; 1.5 h; Inert atmosphere; 2: N,O-dimethylacetohydroxamic acid in tetrahydrofuran; hexane T=-60°C; 1 h; Inert atmosphere;
参考文献
Zhong, Yong-Li; Lindale, Matthew G.; Yasuda, Nobuyoshi
Tetrahedron Letters, 2009 , vol. 50, # 20 p. 2293 - 2297
反应条件
1: hex-1-yne With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 1 h; 2: N,O-dimethylacetohydroxamic acid in tetrahydrofuran; hexane T=20°C; 1.5 h;
参考文献
Lai, To Leung; Sze, Kar Leung; Chiu, Pauline
Organic Letters, 2005 , vol. 7, # 23 p. 5249 - 5252
反应条件
ammonium acetate; n-butyllithium in tetrahydrofuran; diethyl ether; hexane
参考文献
Baxter, Andrew; Brough, Stephen; Faull, Alan; Johnstone, Craig; McInally, Thomas
Patent: US2002/107252 A1, 2002 ;
反应条件
1: 2-fluoro-pyridine With n-butyllithium; diisopropylamine in tetrahydrofuran; hexane T=-70°C; 0.5 h; 2: N,O-dimethylacetohydroxamic acid in tetrahydrofuran; hexane T=-70 - -60°C;
参考文献
Beutner, Gregory L.; Kuethe, Jeffrey T.; Yasuda, Nobuyoshi
Tetrahedron Letters, 2009 , vol. 50, # 7 p. 781 - 784
反应条件
1: p-bromophenyl bromide With n-butyllithium in tetrahydrofuran T=-78°C; 0.5 h; 2: N,O-dimethylacetohydroxamic acid in tetrahydrofuran T=-78°C;
参考文献
Caron, Stephane; Do, Nga M.
Synlett, 2004 , # 8 p. 1440 - 1442
反应条件
1: (E)-4-methoxyacetophenone tosylhydrazone With Mes2Mg; lithium chloride in tetrahydrofuran T=40°C; Shapiro reaction; 3 h; 2: N,O-dimethylacetohydroxamic acid in tetrahydrofuran T=0°C; 2 h; 3: With water-d2 in tetrahydrofuran
参考文献
Kerr, William J.; Morrison, Angus J.; Pazicky, Marek; Weber, Tina
Organic Letters, 2012 , vol. 14, # 9 p. 2250 - 2253
反应条件
1: in diethyl ether T=0 - 20°C; 2 h; 2: With hydrogenchloride in diethyl ether; water
参考文献
WO2003/87037 A1, ;
Page/Page column 125 ;
WO 03/087037 A1
反应条件
in diethyl ether T=0 - 20°C; 2 h;
参考文献
WO2005/27837 A2, ;
Page/Page column 76-77 ;
WO 2005/027837 A2
反应条件
1: vinyl-magnesium bromide; N,O-dimethylacetohydroxamic acid in tetrahydrofuran T=0 - 20°C; 1.16667 h; 2: N-Benzylbenzylamine in tetrahydrofuran; water T=20°C; 0.333333 h; Further stages.;
参考文献
Gomtsyan; Koenig; Lee
Journal of Organic Chemistry, 2001 , vol. 66, # 10 p. 3613 - 3616
