1-氯-2-(氯甲基)-3,5-二氧杂己烷合成路线 （共 11 条）
反应条件
phosphorus pentoxide in dichloromethane
参考文献
Crimmins, Michael T.; Diaz, Caroline J.; Emmitte, Kyle A.
Heterocycles, 2004 , vol. 62, p. 179 - 183
反应条件
sodium in tetrahydrofuran T=-78 - 20°C; 12 h;
参考文献
Janicki, Slawomir Z.; Fairgrieve, Jennifer M.; Petillo, Peter A.
Journal of Organic Chemistry, 1998 , vol. 63, # 11 p. 3694 - 3700
反应条件
trimethylhexadecylammonium chloride T=30°C; 20 h;
参考文献
Gu, Xue-Ping; Ikeda, Isao; Okahara, Mitsuo
Bulletin of the Chemical Society of Japan, 1987 , vol. 60, # 1 p. 397 - 398
反应条件
potassium tert-butylate in tetrahydrofuran T=-13 - 20°C; 12 h;
参考文献
Janicki, Slawomir Z.; Fairgrieve, Jennifer M.; Petillo, Peter A.
Journal of Organic Chemistry, 1998 , vol. 63, # 11 p. 3694 - 3700
反应条件
sulfuric acid; potassium 1.) 80 deg C, 6 h, 2.) 60 deg C, 30 min; Yield given. Multistep reaction;
参考文献
Gu, Xue-Ping; Ikeda, Isao; Komada, Satoru; Masuyama, Araki; Okahara, Mitsuo
Journal of Organic Chemistry, 1986 , vol. 51, # 26 p. 5425 - 5427
反应条件
1: dimethylformamide / Heating 2: BF3*Et2O / 0 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 31, # 1 p. 144 - 149
反应条件
15-crown-5 in N,N-dimethyl-formamide 48 h; Heating;
参考文献
Beauchamp, Lilia M.; Serling, Barbara L.; Kelsey, John E.; Biron, Karen K.; Collins, Peter; et al.
Journal of Medicinal Chemistry, 1988 , vol. 31, # 1 p. 144 - 149
反应条件
2: H2SO4 View Scheme
参考文献
Beauchamp, Lilia M.; Serling, Barbara L.; Kelsey, John E.; Biron, Karen K.; Collins, Peter; et al.
Journal of Medicinal Chemistry, 1988 , vol. 31, # 1 p. 144 - 149
参考文献
Blanchard
Bulletin de la Societe Chimique de France, 1931 , vol. <4> 49, p. 292
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1929 , vol. 188, p. 504
反应条件
sodium hydroxide; sulfuric acid 1.) dioxane, 60 deg C, 3 h, 2.) RT, 1 h; Yield given. Multistep reaction;
参考文献
Gu, Xue-Ping; Ikeda, Isao; Komada, Satoru; Masuyama, Araki; Okahara, Mitsuo
Journal of Organic Chemistry, 1986 , vol. 51, # 26 p. 5425 - 5427
