4-（二甲氨基）-1，1-二甲氧基-3-丙烯-1-酮合成路线 （共 16 条）
参考文献
Jasco Pharmaceuticals, LLC
Patent: US2012/270892 A1, 2012 ;
Location in patent: Page/Page column 56 ;
US 20120270892 A1
反应条件
in 2-methyl-propan-1-ol
参考文献
Buettelmann, Bernd; Jakob-Roetne, Roland; Knust, Henner; Thomas, Andrew
Patent: US2009/143385 A1, 2009 ;
反应条件
1: NaOMe View Scheme
参考文献
JASCO PHARMACEUTICALS, LLC; BALDINO, Carmen, M.; CASERTA, Justin, L.; LEE, Chee-Seng; NICEWONGER, Robert, B.
Patent: WO2011/103289 A2, 2011 ;
WO 2011/103289 A2
参考文献
Adams, Jerry L.; Boehm, Jeffrey C.; Kassis, Shouki; Gorycki, Peter D.; Webb, Edward F.; Hall, Ralph; Sorenson, Margaret; Lee, John C.; Ayrton, Andrew; Griswold, Don E.; Gallagher, Timothy F.
Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 22 p. 3111 - 3116
反应条件
1: 1,1-Dimethoxy-2-oxo-4-dimethylamino-3-butene; thiourea With sodium methylate in methanol T=0 - 80°C; 46 h; 2: propyl bromide in methanol T=50°C; 5 h;
参考文献
Griffin, John; Lanza, Guido; Yu, Jessen
Patent: US2005/261354 A1, 2005 ;
Location in patent: Page/Page column 87 ;
US 20050261354 A1
反应条件
1: NaOMe View Scheme
参考文献
Boehm, Jeffrey C.; Bower, Michael J.; Gallagher, Timothy F.; Kassis, Shouki; Johnson, Stephen R.; Adams, Jerry L.
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 9 p. 1123 - 1126
反应条件
sodium hydroxide in isopropyl alcohol 20 h; Heating / reflux;
参考文献
Adams, Jerry L.; Boehm, Jeffrey C.; Kassis, Shouki; Gorycki, Peter D.; Webb, Edward F.; Hall, Ralph; Sorenson, Margaret; Lee, John C.; Ayrton, Andrew; Griswold, Don E.; Gallagher, Timothy F.
Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 22 p. 3111 - 3116
反应条件
1: With sodium hydroxide in water T=0 - 20°C; 2: With hydrogenchloride in water 4 h; 3: With sodium hydroxide in water pH=9.4;
参考文献
BASF SE
Patent: US2010/174094 A1, 2010 ;
Location in patent: Page/Page column 16 ;
反应条件
1: With sodium hydroxide in water T=0 - 20°C; 2: With hydrogenchloride in water 4 h; 3: With sodium hydroxide in water pH=9.4;
参考文献
BASF SE
Patent: US2010/174094 A1, 2010 ;
Location in patent: Page/Page column 16 ;
