in tetrahydrofuran; diethyl ether; water

Cp*2Sm(THF)2 in toluene 5 h; Ambient temperaturefurther reagent: SmI2;

sodium chloride in tetrahydrofuran; water

pyridine in dichloromethane T=-50 - -20°C;

triethylamine in water; acetonitrile T=45°C; 1 h;

N-benzyl-N,N,N-triethylammonium chloride; sodium hydrogencarbonate in dichloromethane; water 5 h; Ambient temperature;

1: nicotinamide adenine dinucleotide; pyridoxal 5'-phosphate; [3H]-L-Alanine; ammonium chloride; L-alanine dehydrogenase; alcohol dehydrogenase from Bacillus stearothermophilus; ω-transaminase from Chromobacterium violaceum; sodium hydroxide / water; ethylene glycol dimethyl ether / 24 h / 20 °C / pH 8.5 / |Enzymatic reaction 2: triethylamine / water; acetonitrile / 1 h / 45 °C View Scheme

in chloroform Ambient temperature; Yield given;

(i) ion-exchange resin <Cl- form>, H2O, (ii) /BRN= 1733136/, benzene, (iii) /BRN= 1718733/; Multistep reaction;