Naylor, Matthew A.; Threadgill, Michael D.; Webb, Paul; Stratford, Ian J.; Stephens, Miriam A.; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 19 p. 3573 - 3578
1: 4-bromo-but-1-ene With magnesium in tetrahydrofuran
T=0 - 20°C; Inert atmosphere;
2: formic acid ethyl ester in tetrahydrofuran
T=0 - 20°C; Inert atmosphere;
参考文献
Lemiere, Gilles; Gandon, Vincent; Cariou, Kevin; Hours, Alexandra; Fukuyama, Takahide; et al.
Journal of the American Chemical Society, 2009 , vol. 131, p. 2993 - 3006
magnesium
1) THF 2) THF a) 0 deg C, 1h 2) to r.t.; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Krow, Grant R.; Lee, Yoon B.; Raghavachari, Ramesh; Szczepanski, Steven W.
Tetrahedron, 1991 , vol. 47, # 40 p. 8499 - 8514
magnesium
1) THF 2) THF a) 0 deg C, 1h 2) to r.t.; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Krow, Grant R.; Lee, Yoon B.; Raghavachari, Ramesh; Szczepanski, Steven W.
Tetrahedron, 1991 , vol. 47, # 40 p. 8499 - 8514
magnesium
1) THF 2) THF a) 0 deg C, 1h 2) to r.t.; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Krow, Grant R.; Lee, Yoon B.; Raghavachari, Ramesh; Szczepanski, Steven W.
Tetrahedron, 1991 , vol. 47, # 40 p. 8499 - 8514
