2-(喹啉-2-基)乙酸乙酯合成路线 （共 15 条）
反应条件
PdCl2[dppf] in tetrahydrofuran; water; ethyl acetate
参考文献
Abbott Laboratories; Abbott GmbH and Co. KG
Patent: US2013/5705 A1, 2013 ;
US 20130005705 A1
反应条件
diethyl ether; KNH2 anschliessend Behandeln mit Diaetylcarbonat;
参考文献
Arndt; Eistert
Patent: DE650706 , 1933 ;
Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 23, p. 582
反应条件
1: 2-Methyl quinoline With N,N,N',N,-tetramethylethylenediamine; lithium diisopropyl amide in tetrahydrofuran T=-78°C; 1 h; 2: chloroformic acid ethyl ester in tetrahydrofuran T=-78 - 20°C; 12 h;
参考文献
Jiang, Jinlong; DeVita, Robert J.; Goulet, Mark T.; Wyvratt, Matthew J.; Lo, Jane-L.; Ren, Ning; Yudkovitz, Joel B.; Cui, Jisong; Yang, Yi T.; Cheng, Kang; Rohrer, Susan P.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 7 p. 1795 - 1798
反应条件
tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran; ethylene glycol dimethyl ether 1.5 h; Heating;
参考文献
Yamanaka, Hiroshi; An-naka, Masayuki; Kondo, Yoshinori; Sakamoto, Takao
Chemical & Pharmaceutical Bulletin, 1985 , vol. 33, # 10 p. 4309 - 4313
反应条件
diethyl ether; carbon dioxide Behandeln einer Loesung des Reaktionsprodukts in Aethanol mit Chlorwasserstoff;
参考文献
Clemo; Nath
Journal of the Chemical Society, 1952 , p. 2196
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Leonard; Boyer
Journal of the American Chemical Society, 1950 , vol. 72, p. 2980,2984
反应条件
1,5-diethoxy-3-oxapentane; trichlorophosphate Hydrieren des Reaktionsprodukts an Palladium/Kohle in mit Natriumacetat versetzter Essigsaeure;
参考文献
Kaslow; Nix
Journal of Organic Chemistry, 1951 , vol. 16, p. 895,897
反应条件
1: mineral oil; phthalic acid dibutyl ester / 275 °C 2: POCl3; O,O'-diethyl-diethylene glycol / Hydrieren des Reaktionsprodukts an Palladium/Kohle in mit Natriumacetat versetzter Essigsaeure View Scheme
参考文献
Kaslow; Nix
Journal of Organic Chemistry, 1951 , vol. 16, p. 895,897
参考文献
Zymalkowski; Schauer
Archiv der Pharmazie (Weinheim, Germany), 1957 , vol. 290, p. 218,222
反应条件
1: palladium/BaSO4; ethanol / Hydrogenation 2: ethanolic HCl View Scheme
参考文献
Zymalkowski; Schauer
Archiv der Pharmazie (Weinheim, Germany), 1957 , vol. 290, p. 218,222
参考文献
Borsche; Manteuffel
Justus Liebigs Annalen der Chemie, 1936 , vol. 526, p. 22,33
