3-甲基吡唑-5-甲酸乙酯合成路线 （共 40 条）
反应条件
1: With hydrazine in acetic acid; ethyl acetate T=0 - 20°C; 15 h; 2: With sodium hydrogencarbonate in water; acetic acid; ethyl acetate
参考文献
CRYSTAX PHARMACEUTICALS, S.L.
Patent: WO2009/7399 A1, 2009 ;
Location in patent: Page/Page column 80 ;
反应条件
sodium ethanolate in ethanol T=60°C; 3 h;
参考文献
Doyle, Michael P.; Colsman, Mark R.; Dorow, Roberta L.
Journal of Heterocyclic Chemistry, 1983 , vol. 20, p. 943 - 946
反应条件
diethylamine in dimethyl sulfoxide T=20°C; 24 h; regioselective reaction;
参考文献
Wang, Lei; Huang, Jiayao; Gong, Xiaojie; Wang, Jian
Chemistry - A European Journal, 2013 , vol. 19, # 23 p. 7555 - 7560
反应条件
diethylamine in dimethyl sulfoxide T=20°C; 12 h;
参考文献
Wang, Lei; Huang, Jiayao; Gong, Xiaojie; Wang, Jian
Chemistry - A European Journal, 2013 , vol. 19, # 23 p. 7555 - 7560
反应条件
in octane T=110°C; 1 h;
参考文献
Padwa, Albert; Kulkarni, Yashwant S.; Zhang, Zhijia
Journal of Organic Chemistry, 1990 , vol. 55, # 13 p. 4144 - 4153
反应条件
1: 63 percent / POCl3, pyridine / 1) 0 deg C, 6 h, 2) r.t., 12 h 2: 88 percent / octane / 1 h / 110 °C / other vinyl diazo carboxylates View Scheme
参考文献
Padwa, Albert; Kulkarni, Yashwant S.; Zhang, Zhijia
Journal of Organic Chemistry, 1990 , vol. 55, # 13 p. 4144 - 4153
反应条件
unter Einleiten von HCl;
参考文献
Musante; Mugnaini
Gazzetta Chimica Italiana, 1947 , vol. 77, p. 182,193
反应条件
1: copper-powder; ethanone; N2H2+H2O 2: unter Einleiten von HCl View Scheme
参考文献
Cusmano
Gazzetta Chimica Italiana, 1940 , vol. 70, p. 240,244
参考文献
v. Auwers; Hollmann
Chemische Berichte, 1926 , vol. 59, p. 606,1296
反应条件
methanol; sodium methylate
参考文献
Dal Monte et al.
Gazzetta Chimica Italiana, 1956 , vol. 86, p. 797,808
