5-乙氧基-2-吡咯烷酮合成路线 （共 52 条）
反应条件
1: 1.) n-butyllithium / 1.) THF, hexane, -70 deg C, 45 min, 2.) THF, hexane, -70 deg C, 2 h 2: 57 percent / H2 / 10percent Pd/C / aq. ethanol / 760 Torr / Ambient temperature View Scheme
参考文献
Toja, E; Gorini, C; Zirotti, C; Barzaghi, F; Galliani, G
European Journal of Medicinal Chemistry, 1991 , vol. 26, # 4 p. 403 - 413
反应条件
n-butyllithium 1.) THF, hexane, -70 deg C, 45 min, 2.) THF, hexane, -70 deg C, 2 h; Yield given. Multistep reaction;
参考文献
Toja, E; Gorini, C; Zirotti, C; Barzaghi, F; Galliani, G
European Journal of Medicinal Chemistry, 1991 , vol. 26, # 4 p. 403 - 413
反应条件
n-butyllithium 1.) THF, hexane, -70 deg C, 45 min, 2.) THF, hexane, -70 deg C, 2 h; Yield given. Multistep reaction;
参考文献
Toja, E; Gorini, C; Zirotti, C; Barzaghi, F; Galliani, G
European Journal of Medicinal Chemistry, 1991 , vol. 26, # 4 p. 403 - 413
反应条件
magnesium 1.) ether, 2.) THF, reflux, 0.5 h; Yield given. Multistep reaction;
参考文献
Vedejs; Campbell Jr.; Gadwood; et al.
Journal of Organic Chemistry, 1982 , vol. 47, # 8 p. 1534 - 1546
反应条件
1: in tetrahydrofuran T=0°C; 3 h; Inert atmosphereReflux; 2: With ammonium chloride in tetrahydrofuran Inert atmosphere; Product distribution / selectivity;
参考文献
Targeon SAS
Patent: EP2537827 A1, 2012 ;
Location in patent: Page/Page column 7-8 ;
反应条件
1: 2-oxo-5-ethoxy pyrrolidine With ethyl magnesium chloride in tetrahydrofuran T=-15°C; 0.5 h; Inert atmosphere; 2: vinyl-magnesium chloride in tetrahydrofuran 2 h; RefluxInert atmosphere; 3: With ammonium chloride in tetrahydrofuran T=20°C; Inert atmosphere; Product distribution / selectivity;
参考文献
Targeon SAS
Patent: EP2537827 A1, 2012 ;
Location in patent: Page/Page column 8-9 ;
反应条件
hydrogenchloride 1 h; Heating;
参考文献
Heterocycles, , vol. 14, # 9 p. 1245 - 1249
反应条件
1: 51 percent / Amberlyst 15 / 5 h / 21 °C 2: 1.) n-butyllithium / 1.) THF, hexane, -60 deg C, 15 min, 2.) THF, hexane, from -60 deg C to RT View Scheme
参考文献
Toja, E; Gorini, C; Zirotti, C; Barzaghi, F; Galliani, G
European Journal of Medicinal Chemistry, 1991 , vol. 26, # 4 p. 415 - 422
反应条件
hydrogenchloride; sodium tetrahydroborate
T=0°C; 1 h;
参考文献
Daoust, Benoit; Lessard, Jean
Tetrahedron, 1999 , vol. 55, # 12 p. 3495 - 3514
反应条件
sodium borohydride in ethanol; water
参考文献
Bayer Aktiengesellschaft
Patent: US6489490 B1, 2002 ;
