1,1,1-三甲基-N-苯基哌啶合成路线 （共 76 条）
反应条件
in hexane 5 h; Ambient temperature;
参考文献
Journal of Organic Chemistry, , vol. 48, # 22 p. 4111 - 4113
参考文献
Klebe,J.F. et al.
Journal of the American Chemical Society, 1964 , vol. 86, p. 4400 - 4406
反应条件
tri-ruthenium(0)dodecacarbonyl T=100°C; P=15514.4 Torr; 20 h;
参考文献
Zoeckler, M. T.; Laine, R. M.
Journal of Organic Chemistry, 1983 , vol. 48, # 15 p. 2539 - 2543
反应条件
sodium methylate in tetrahydrofuran; diethylene glycol dimethyl ether T=40°C; 18 h;
参考文献
Ando, Wataru; Tsumaki, Hidetoshi
Chemistry Letters, 1981 , p. 693 - 694
反应条件
hydrogenchloride; n-butyllithium 1.) THF, hexane, 0 deg C, 0.5 h; room temperature, overnight, 2.) ether, 0 deg C; Yield given. Multistep reaction;
参考文献
Calverley, Martin J.
Synthetic Communications, 1983 , vol. 13, # 7 p. 601 - 610
反应条件
1: HN(SiMe3)(Ph) With n-butyl-magnesium bromide in anhydrous butyl ether T=0 - 100°C; 1 h; Inert atmosphere; 2: 1-bromo-4-methoxy-benzene With lithium bromide; iron(II) chloride in anhydrous butyl ether T=140°C; 12 h; Inert atmosphere;
参考文献
Hatakeyama, Takuji; Imayoshi, Ryuji; Yoshimoto, Yuya; Ghorai, Sujit K.; Jin, Masayoshi; Takaya, Hikaru; Norisuye, Kazuhiro; Sohrin, Yoshiki; Nakamura, Masaharu
Journal of the American Chemical Society, 2012 , vol. 134, # 50 p. 20262 - 20265
反应条件
acetic acid 1) CH2Cl2, (-10)-(-15) deg C, 2 h; reflux, 3 h; 2) (-10)-(-15) deg C, 3 h; Multistep reaction. Further byproducts given;
参考文献
Kanetani, Fujio; Okada, Eiji; Negoro, Kenji
Bulletin of the Chemical Society of Japan, 1986 , vol. 59, # 8 p. 2517 - 2520
反应条件
1: HN(SiMe3)(Ph) With n-butyl-magnesium bromide in anhydrous butyl ether T=0 - 100°C; 1 h; Inert atmosphere; 2: 1-bromo-2-methyl benzene With lithium bromide; iron(II) chloride in anhydrous butyl ether T=140°C; 72 h; Inert atmosphere;
参考文献
Hatakeyama, Takuji; Imayoshi, Ryuji; Yoshimoto, Yuya; Ghorai, Sujit K.; Jin, Masayoshi; Takaya, Hikaru; Norisuye, Kazuhiro; Sohrin, Yoshiki; Nakamura, Masaharu
Journal of the American Chemical Society, 2012 , vol. 134, # 50 p. 20262 - 20265
反应条件
tetrabutyl ammonium fluoride in N,N-dimethyl-formamide T=20 - 25°C; 0.0833333 h;
参考文献
Iida, Akira; Horii, Atsushi; Misaki, Tomonori; Tanabe, Yoo
Synthesis, 2005 , # 16 art. no. F06305SS, p. 2677 - 2682
反应条件
tetrabutyl ammonium fluoride in N,N-dimethyl-formamide T=20°C; 3.5 h;
参考文献
Iida, Akira; Horii, Atsushi; Misaki, Tomonori; Tanabe, Yoo
Synthesis, 2005 , # 16 art. no. F06305SS, p. 2677 - 2682
