2-二环己膦基-2'-(N,N-二甲胺)-联苯合成路线 （共 11 条）
反应条件
1: N,N-dimethyl-2-chloroaniline With magnesium; ethylene dibromide in tetrahydrofuran Metallation; 29.5 h; Heating; 2: 1-bromo-2-chloro-benzene in tetrahydrofuran T=60°C; Arylation; 2 h; 3: chloro-dicyclohexylphosphine With copper(l) chloride in tetrahydrofuran T=20°C; Substitution; 9 h; Further stages.;
参考文献
Tomori, Hiroshi; Fox, Joseph M.; Buchwald, Stephen L.
Journal of Organic Chemistry, 2000 , vol. 65, # 17 p. 5334 - 5341
反应条件
1: 2-Bromo-N,N-dimethylaniline With magnesium in tetrahydrofuran Heating; 2: 1-bromo-2-chloro-benzene in tetrahydrofuran T=60°C; 2.25 h; 3: chloro-dicyclohexylphosphine With copper(l) chloride in tetrahydrofuran; diethyl ether T=20°C; 1 h; Further stages.;
参考文献
Kaye, Steven; Fox, Joseph M.; Hicks, Frederick A.; Buchwald, Stephen L.
Advanced Synthesis and Catalysis, 2001 , vol. 343, # 8 p. 789 - 794
反应条件
1.1: PCl3 / toluene / 0 °C 2.1: Mg tunings / tetrahydrofuran / Heating 2.2: tetrahydrofuran 2.3: CuI; LiBr / tetrahydrofuran View Scheme
参考文献
Advanced Synthesis and Catalysis, , vol. 348, # 1-2 p. 23 - 39
反应条件
1.1: 100 kg / alkaline 2.1: Mg tunings / tetrahydrofuran / Heating 2.2: tetrahydrofuran 2.3: CuI; LiBr / tetrahydrofuran View Scheme
参考文献
Advanced Synthesis and Catalysis, , vol. 348, # 1-2 p. 23 - 39
反应条件
Multistep reaction.;
参考文献
Tomori, Hiroshi; Fox, Joseph M.; Buchwald, Stephen L.
Journal of Organic Chemistry, 2000 , vol. 65, # 17 p. 5334 - 5341
反应条件
palladium diacetate in 1,4-dioxane
反应条件
tris-(dibenzylideneacetone)dipalladium(0) in toluene
参考文献
Buchwald, Stephen L.; Huang, Xiaohua; Zim, Danilo
Patent: US2004/171833 A1, 2004 ;
反应条件
potassium tert-butylate; acetic acid; palladium diacetate in tetrahydrofuran
参考文献
Pfizer Inc
Patent: US2004/176390 A1, 2004 ;
反应条件
tris(dibenzylideneacetone)dipalladium (0) in acetone; toluene
参考文献
Dainippon Sumitomo Pharma Co., Ltd.
Patent: EP1837329 A1, 2007 ;
反应条件
n-butyllithium; 1,1,1,3,3,3-hexamethyl-disilazane; Pd2dba3 in toluene
参考文献
Renaud, Johanne; Missbach, Martin; McKie, Jeffrey A.; Bhagwat, Shripad S.
Patent: US2004/92572 A1, 2004 ;
