(R)-(+)-1-苯基-1-丙醇合成路线 （共 130 条）
反应条件
N-ethyl-N,N-diisopropylamine; CF3-PIP in chloroform T=0°C; 6 - 8.25 h; Resolution of racemate; Product distribution / selectivity;
参考文献
US2005/256150 A1, ;
Page/Page column 15; 16; 17; 18 ;
反应条件
potassium hydroxide in methanol T=20°C;
参考文献
US2005/256150 A1, ;
Page/Page column 21 ;
反应条件
(R)-(+)-N-methylbenzoguanidine; trimethylacetic anhydride in diethyl ether T=20°C; 12 h; Resolution of racemate; optical yield given as percent ee;
参考文献
Organic and Biomolecular Chemistry, , vol. 9, # 20 p. 7092 - 7096
反应条件
titanium(IV) isopropylate; (R,R)-1,1'-bis(1-ferrocenylethanol) in hexane; toluene T=20°C; 48 h;
参考文献
Journal of Organometalic Chemistry, , vol. 649, # 2 p. 258 - 267
反应条件
[(C4Ph4COHOCC4Ph4)(μ-H)][(CO)4Ru2]; Novozym(R) 435; 2,4-dimethylpentan-3-one in toluene T=70°C; P=142.511 Torr; 40 h;
参考文献
Tetrahedron Asymmetry, , vol. 16, # 9 p. 1603 - 1610
反应条件
1: trichlorosilane; [(R)-1,1'-spirobiindane-7,7'-dioxy][((R)-PhMeCH)2N]phosphane / [Pd(η3-allyl)Cl]2 / 36 h / 15 - 20 °C 2: H2O2; KF; KHCO3 / methanol; tetrahydrofuran View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 15, # 14 p. 2231 - 2234
反应条件
titanium(IV) isopropylate; DPP-H8-BINOL in tetrahydrofuran T=66°C; 2 h; Inert atmosphere; optical yield given as percent eeenantioselective reaction;
参考文献
European Journal of Organic Chemistry, , # 26 p. 4405 - 4407
反应条件
Birman's catalyst; nicotinic anhydride in dichloromethane T=0°C; 12 h; Resolution of racemate; optical yield given as percent eeenantioselective reaction;
参考文献
Heterocycles, , vol. 80, # 1 p. 169 - 175
反应条件
(-)-(R,R)-TADDOL in tetrahydrofuran T=-105°C; Title compound not separated from byproducts;
参考文献
Tetrahedron, , vol. 50, # 20 p. 6117 - 6128
反应条件
titanium(IV) isopropylate; (R)-2,2'-dihydroxy-1,1'-binaphthyl in tetrahydrofuran; toluene T=0°C; 5 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Journal of the American Chemical Society, , vol. 119, # 17 p. 4080 - 4081
