1-(3-三氟甲基苯基)哌嗪合成路线 （共 13 条）
反应条件
hydrogenchloride; borane; sodium carbonate in tetrahydrofuran; water; acetone; toluene
参考文献
Schaus, John Mehnert; Thompson, Dennis Charles; Thor, Karl Bruce
Patent: US2004/67962 A1, 2004 ;
US 20040067962 A1
反应条件
formic acid
Heating;
参考文献
Romanelli; Manetti; Scapecchi; Borea; Dei; Bartolini; Ghelardini; Gualtieri; Guandalini; Varani
Journal of Medicinal Chemistry, 2001 , vol. 44, # 23 p. 3946 - 3955
反应条件
toluene-4-sulfonic acid in benzene
Heating;
参考文献
Pratap, Ram; Gupta, R. C.; Srimal, R. C.; Anand, Nitya
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1980 , vol. 19, # 8 p. 695 - 698
反应条件
sodium hydroxide in acetone
T=20°C; 48 h;
参考文献
Mahesh; Venkatesha Perumal; Pandi
Pharmazie, 2005 , vol. 60, # 6 p. 411 - 414
反应条件
in toluene
Alkylation; 6 h; Heating;
参考文献
Caliendo, Giuseppe; Fiorino, Ferdinando; Grieco, Paolo; Perissutti, Elisa; Santagada, Vincenzo; Severino, Beatrice; Bruni, Giancarlo; Romeo, Maria Rosaria
Bioorganic and Medicinal Chemistry, 2000 , vol. 8, # 3 p. 533 - 538
反应条件
triethylamine in toluene
12 h; Ambient temperature;
参考文献
Saxena, Anil K.; Arunamurthy, V.; Patnaik, G. K.; Jain, Padam C.; Anand, Nitya
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1980 , vol. 19, # 10 p. 873 - 878
反应条件
1: With acetic acid in water; acetonitrile
T=20°C; 4 h;
2: With sodium hydroxide in water; acetonitrile
参考文献
LUPIN LIMITED
Patent: WO2004/26828 A1, 2004 ;
Location in patent: Page 25-26 ;
反应条件
1: Na2CO3 / dimethylformamide / 22 h / Ambient temperature
2: 38 percent / dimethylformamide / 1 h / Heating
View Scheme
参考文献
Bermann; Bonte; Lesieur-Demarquilly; et al.
European Journal of Medicinal Chemistry, 1982 , vol. 17, # 1 p. 85 - 88
反应条件
triethylamine in 1,4-dioxane
15 h; Ambient temperature;
参考文献
Bermann; Berthelot; Bonte; Debaert; Lesieur; Brunet; Cazin; Luyckx
Arzneimittel-Forschung/Drug Research, 1982 , vol. 32, # 6 p. 604 - 610
反应条件
acetic acid in ethanol
5 h; Heating;
参考文献
Shiozawa; Ichikawa; Komuro; Idzu; Ishikawa; Kurashige; Miyazaki; Yamanaka; Sakamoto
Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 2 p. 553 - 563
