4-邻苯二甲酰亚氨基乙酰乙酸乙酯合成路线 （共 7 条）
反应条件
1: 2,2-Dimethyl-[1,3]dioxane-4,6-dione; 1,3-dihydro-1,3-dioxo-2H-isoindole-2-acetic acid With 4-(N,N-dimethlyamino)pyridine; dicyclohexyl-carbodiimide in dichloromethane T=0 - 20°C; 16 h; 2: ethanol T=70°C; 4 h;
参考文献
Takeda Pharmaceutical Company Limited
Patent: US2011/152273 A1, 2011 ;
Location in patent: Page/Page column 32 ;
反应条件
1: DMAP; isopropenyl chloroformate / CH2Cl2 / 1.5 h / -5 °C 2: 78 percent / benzene / 4 h / Heating View Scheme
参考文献
Bunce, Richard A.; Schilling III, Curtis L.; Rivera, Mario
Journal of Labelled Compounds and Radiopharmaceuticals, 1997 , vol. 39, # 8 p. 669 - 675
反应条件
in benzene Ring cleavage; esterification; 4 h; Heating;
参考文献
Li, Baoqing; Franck, Richard W.
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 17 p. 2629 - 2634
反应条件
isopropylmagnesium chloride 1.) a) 0 deg C, 30 min, b) 25 deg C, 45 min, c) 40 deg C, 30 min, 2.) THF, a) 0 deg C, b) room temperature, 4 h; Yield given. Multistep reaction;
参考文献
Jones, Raymond C. F.; Bhalay, Gurdip; Carter, Paul A.; Duller, Kathryn A. M.; Dunn, Stephen H.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1999 , # 7 p. 765 - 776
参考文献
Gabriel; Colman
Chemische Berichte, 1909 , vol. 42, p. 1245
反应条件
pyridine 1.) CH2Cl2, 0-20 deg C, 2.) reflux, 3 h; Yield given. Multistep reaction;
参考文献
Bunce, Richard A.; Schilling III, Curtis L.; Rivera, Mario
Journal of Labelled Compounds and Radiopharmaceuticals, 1997 , vol. 39, # 8 p. 669 - 675
参考文献
Gabriel; Colman
Chemische Berichte, 1909 , vol. 42, p. 1245
