(±)-3-氯-1,2-丙二醇合成路线 （共 308 条）
反应条件
sodium hydroxide; sodium azide; acid phosphatase; pyruvate kinase; Phosphoenolpyruvate; glycerol kinase from Streptomyces canus; potassium chloride; adenosine 5'-triphosphoric acid; 2-hydroxyethanethiol; magnesium chloride 1.) H2O, 25 deg C; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Keith Chenault; Chafin, Laura F.; Liehr, Sebastian
Journal of Organic Chemistry, 1998 , vol. 63, # 12 p. 4039 - 4045
参考文献
Guth
Z.B., 1903 , vol. 44, p. 93
Full Text Show Details
Berthelot
Annales de Chimie (Cachan, France), 1854 , vol. <3> 41, p. 295
Annales de Chimie (Cachan, France), 1856 , vol. 46, p. 482
反应条件
potassium phosphate; [(R,R)-(salen)Co(II)]2*Al(NO3)3 in tetrahydrofuran T=20°C; 7 h;
参考文献
Thakur, Santosh Singh; Chen, Shu-Wei; Li, Wenji; Shin, Chang-Kyo; Kim, Seong-Jin; Koo, Yoon-Mo; Kim, Geon-Joong
Journal of Organometallic Chemistry, 2006 , vol. 691, # 9 p. 1862 - 1872
反应条件
sodium hydroxide in water T=17 - 42°C; 0.270167 h;
参考文献
BORREGAARD AS; TJOSAaS, Freddy
Patent: WO2012/108777 A1, 2012 ;
Location in patent: Page/Page column 8 ;
反应条件
1: phenol With sodium hydroxide in ethanol; water 0.166667 h; Reflux; 2: 1,2-dihydroxy-3-chloropropane in ethanol; water Reflux;
参考文献
Guimond, Nicolas; MacDonald, Melissa J.; Lemieux, Valerie; Beauchemin, Andre M.
Journal of the American Chemical Society, 2012 , vol. 134, # 40 p. 16571 - 16577,7
Title/Abstract Full Text Show Details
Guimond, Nicolas; MacDonald, Melissa J.; Lemieux, Valerie; Beauchemin, Andre M.
Journal of the American Chemical Society, 2012 , vol. 134, # 40 p. 16571 - 16577
反应条件
in benzyl alcohol 0.5 h; Heating;
参考文献
Birkofer, Leonhard; Stuhl, Oskar
Journal of Organometallic Chemistry, 1980 , vol. 187, # 1 p. 21 - 29
反应条件
lithium hydroxide in methanol
参考文献
Abbott Laboratories
Patent: US5705692 A1, 1998 ;
反应条件
sodium ethanolate in ethanol Heating;
参考文献
Pala,G. et al.
Farmaco, Edizione Scientifica, 1963 , vol. 18, p. 619 - 642
参考文献
Srinivasa Reddy, Battula
Patent: US2011/306773 A1, 2011 ;
Location in patent: Page/Page column 2 ;
反应条件
in ethanol sodium hypophosphite monohydrate dissolved in ethanol, 3-chloro-1,2-propanediol added; H2POOH detected by (1)H NMR, decompn. during distn.;
参考文献
Devedjiev, I.; Ganev, V.; Stefanova, R.; Borissov, G.
Phosphorus and Sulfur and the Related Elements, 1988 , vol. 35, p. 261 - 266
