2-氰基-3-硝基-6-氯吡啶合成路线 （共 20 条）
反应条件
in 1-methyl-pyrrolidin-2-one T=180°C; P=4500.45 Torr; 0.25 h; Microwave irradiation;
参考文献
PIERRE FABRE MEDICAMENT; KRUCZYNSKI, Anna; CREANCIER, Laurent; KALOUN, El Bachir; BEDJEGUELAL, Karim; RABOT, Rémi
Patent: WO2014/16434 A1, 2014 ;
Location in patent: Page/Page column 61-62 ;
反应条件
in 1-methyl-pyrrolidin-2-one T=20 - 180°C; 0.666667 h;
参考文献
CHEMIZON, A DIVISION OF OPTOMAGIC CO., LTD.
Patent: US2012/238587 A1, 2012 ;
Location in patent: Page/Page column 15 ;
US 20120238587 A1
反应条件
in various solvent(s) T=178 - 182°C; 0.25 h;
参考文献
Colbry; Elslager; Werbel
Journal of Heterocyclic Chemistry, 1984 , vol. 21, # 5 p. 1521 - 1525
反应条件
T=180°C; P=4500.45 Torr; 0.25 h; Microwave irradiation;
参考文献
PIERRE FABRE MEDICAMENT; KALOUN, El Bachir; BEDJEGUELAL, Karim; RABOT, Rémi; KRUCZYNSKI, Anna; SCHMITT, Philippe; PEREZ, Michel; RAHIER, Nicolas
Patent: US2013/85144 A1, 2013 ;
Location in patent: Paragraph 0350; 0351 ;
反应条件
1: 73 percent / 90percent H2SO4 / 3.5 h / 70 °C 2: H2 / Pd/C / ethyl acetate; methanol / 144 h / 3102.9 Torr 3: 42 h View Scheme
参考文献
Rewcastle, Gordon W.; Palmer, Brian D.; Thompson, Andrew M.; Bridges, Alexander J.; Cody, Donna R.; Zhou, Hairong; Fry, David W.; McMichael, Amy; Denny, William A.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 9 p. 1823 - 1835
反应条件
1: 73 percent / 90percent H2SO4 / 3.5 h / 70 °C 2: H2 / Pd/C / ethyl acetate; methanol / 144 h / 3102.9 Torr View Scheme
参考文献
Rewcastle, Gordon W.; Palmer, Brian D.; Thompson, Andrew M.; Bridges, Alexander J.; Cody, Donna R.; Zhou, Hairong; Fry, David W.; McMichael, Amy; Denny, William A.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 9 p. 1823 - 1835
反应条件
1: 73 percent / 90percent H2SO4 / 3.5 h / 70 °C 2: H2 / 5percent Pd/C / ethyl acetate / 3102.9 Torr 3: 18 h / Heating 4: 73 percent / POCl3 / 3 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 39, # 9 p. 1823 - 1835
反应条件
1: 73 percent / 90percent H2SO4 / 3.5 h / 70 °C 2: H2 / Pd/C / ethyl acetate; methanol / 144 h / 3102.9 Torr 3: 42 h 4: 86 percent / POCl3 / 4 h / Heating View Scheme
参考文献
Rewcastle, Gordon W.; Palmer, Brian D.; Thompson, Andrew M.; Bridges, Alexander J.; Cody, Donna R.; Zhou, Hairong; Fry, David W.; McMichael, Amy; Denny, William A.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 9 p. 1823 - 1835
反应条件
1: With hydrogenchloride; iron in ethanol; water 0.5 h; Reflux; 2: With ammonia in diethyl ether; ethanol
参考文献
SHENYANG PHARMACEUTICAL UNIVERSITY
Patent: US2011/183972 A1, 2011 ;
Location in patent: Page/Page column 12-13 ;
US 20110183972 A1
反应条件
1: With ethanol; tin(ll) chloride T=90°C; 3 h; 2: With sodium hydroxide; sodium hydrogencarbonate in water; ethyl acetate pH=7 - 9;
参考文献
ELI LILLY AND COMPANY
Patent: WO2005/97805 A1, 2005 ;
Location in patent: Page/Page column 49 ;
