反应条件
1: cyclohexylacetylene; 2-bromo-N-(trifluoroacetyl)aniline With bis(benzonitrile)palladium(II) dichloride; tetrabutylammomium bromide; caesium carbonate; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl in N,N-dimethyl-formamide T=80°C; Sonogashira Cross-Coupling; 12 h; Inert atmosphereSealed tube; 2: chlorobenzene in N,N-dimethyl-formamide T=80°C; 1 h; Inert atmosphereSealed tube; ConcentrationReagent/catalyst; regiospecific reaction;
参考文献
Lu, Bruce Z.; Wei, Han-Xun; Zhang, Yongda; Zhao, Wenyi; Dufour, Marine; Li, Guisheng; Farina, Vittorio; Senanayake, Chris H.
Journal of Organic Chemistry, 2013 , vol. 78, # 9 p. 4558 - 4562