1,2,3,4-四氢异喹啉合成路线 （共 340 条）
反应条件
trifluoroacetic anhydride in tetrahydrofuran
参考文献
Lubisch, Wilfried; Haupt, Andreas
Patent: US2007/219182 A1, 2007 ;
反应条件
1: copper(l) iodide; potassium phosphate / ethylene glycol; isopropyl alcohol / 24 h / 20 - 90 °C / Inert atmosphere
2: 2,4,5,7-tetrabromofluorescein / N,N-dimethyl-formamide / 10 h / 20 °C / Irradiation
View Scheme
参考文献
Tanoue, Arata; Yoo, Woo-Jin; Kobayashi, Shu
Organic Letters, 2014 , vol. 16, # 9 p. 2346 - 2349
反应条件
1.1: potassium phosphate; copper(l) iodide / ethylene glycol; isopropyl alcohol / 24 h / 80 °C
2.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / 0.5 h / 20 °C
2.2: 20 °C
3.1: ammonia; hydrogen / methanol / 4 h / 20 °C / 5171.62 Torr
4.1: (-)-Dibenzoyl-L-tartaric acid / isopropyl alcohol; water / 24 h / 20 °C
5.1: triethylamine; 4-(N,N-dimethlyamino)pyridine / dichloromethane / |Cooling with ice
6.1: ammonium cerium (IV) nitrate / water; acetonitrile / 0.08 h / 0 °C
7.1: sodium hydroxide / dichloromethane / 0.5 h / 20 °C
7.2: 2 h / |Reflux
View Scheme
参考文献
Tsang, Althea S.-K.; Ingram, Katrin; Keiser, Jennifer; Hibbert, D. Brynn; Todd, Matthew H.
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 30 p. 4921 - 4924
反应条件
sodium tetrahydroborate; 2-chloropyridine hydrochloride in tetrahydrofuran
T=70°C; Alkylation; Reductive amination; 15 h;
参考文献
Perrio-Huard, Cecile; Aubert, Catherine; Lasne, Marie-Claire
Journal of the Chemical Society, Perkin Transactions 1, 2000 , # 3 p. 311 - 316
反应条件
ethyl (triphenylphosphoranylidene)acetate in dichloromethane
T=20°C; 168 h;
参考文献
Desmaele, Didier
Tetrahedron Letters, 1996 , vol. 37, # 8 p. 1233 - 1236
反应条件
1: 88.2 percent / CH2Cl2 / 1 h / 20 °C
2: 75 percent / LiAlH4 / tetrahydrofuran / 4 h / 20 °C
View Scheme
参考文献
Sugiura, Michiharu; Asai, Koosuke; Hatano, Keiichiro; Kurono, Yukihisa; Hamada, Yoshiki
Heterocycles, 2000 , vol. 53, # 4 p. 821 - 830
反应条件
in tetrahydrofuran
T=20°C; 24 h;
参考文献
Huang, Ling; Zhao, Jianzhang
Chemical Communications, 2013 , vol. 49, # 36 p. 3751 - 3753
反应条件
1: With titanium(IV) isopropylate
T=75°C; 6 h;
2: With sodium tetrahydroborate in ethanol
T=20°C; 3 h;
参考文献
Kumpaty, Hephzibah J.; Bhattacharyya, Sukanta
Synthesis, 2005 , # 13 art. no. M07404SS, p. 2205 - 2209
反应条件
chlorosulfonic acid in dichloromethane
参考文献
SmithKline Corporation
Patent: US4350698 A1, 1982 ;
参考文献
Wilson; Lutz; Jordan
Journal of Organic Chemistry, 1947 , vol. 12, p. 778
