5-氯-2-氰基吡啶合成路线

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ELI LILLY AND COMPANY
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40473-01-62-溴-5-氯吡啶

89809-64-35-氯-2-氰基吡啶

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WO2010/132615 A1, ;

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1851-22-53-氯吡啶 N-氧化物+

7677-24-9三甲基氰硅烷

89809-64-35-氯-2-氰基吡啶+

38180-46-03-氯-2-氰基吡啶

参考文献

Chemical and Pharmaceutical Bulletin, , vol. 33, # 2 p. 565 - 571

544-92-3氰化亚铜+

244221-57-65-氯-2-碘嘧啶

89809-64-35-氯-2-氰基吡啶

参考文献

Zhang, Han-Zhong; Kasibhatla, Shailaja; Kuemmerle, Jared; Kemnitzer, William; Ollis-Mason, Kristin; Qiu, Ling; Crogan-Grundy, Candace; Tseng, Ben; Drewe, John; Cai, Sui Xiong
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16110-09-12,5-二氯吡啶

89809-64-35-氯-2-氰基吡啶

参考文献

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89809-64-35-氯-2-氰基吡啶

参考文献

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4513-94-4吡咯-2-腈+

67-66-3氯仿

89809-64-35-氯-2-氰基吡啶+

38180-46-03-氯-2-氰基吡啶

参考文献

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 1431 - 1435

89809-64-35-氯-2-氰基吡啶+

51269-82-03-氯-5-氰甲基吡啶

参考文献

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 1431 - 1435

460-19-5氰+

126-99-82-氯-1.3-丁二烯

89809-64-35-氯-2-氰基吡啶+

19235-89-34-氯-2-氰基吡啶

参考文献

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89809-64-35-氯-2-氰基吡啶

327056-62-22-氰基-5-氟吡啶

参考文献

ELI LILLY AND COMPANY
Patent: WO2005/66126 A1, 2005 ;
Location in patent: Page/Page column 75-76 ;
WO 2005/066126 A1