3-羟基-3,3-二苯基丙酸乙酯合成路线 （共 18 条）
反应条件
triethylsilane; boron trifluoride diethyl etherate in dichloromethane T=0°C; 0.5 h; further temperature; Yield given. Yields of byproduct given;
参考文献
Orfanopoulos, Michael; Smonou, Ioulia
Synthetic Communications, 1988 , vol. 18, # 8 p. 833 - 840
参考文献
RANBAXY LABORATORIES LIMITED
Patent: WO2006/117754 A1, 2006 ;
Location in patent: Page/Page column 21-22 ;
WO 2006/117754 A1
反应条件
ammonium chloride; zinc
Reformatsky reaction; 0.0138889 h; microwave irradiation;
参考文献
Ross, Nathan A.; Bartsch, Richard A.
Journal of Organic Chemistry, 2003 , vol. 68, # 2 p. 360 - 366
反应条件
1: ethyl acetate With lithium diisopropyl amide in hexane
T=-78°C; 0.5 h;
2: benzophenone in hexane
T=-78 - 20°C; 4 h; Further stages.;
参考文献
Groundwater, Paul W.; Garnett, Ian; Morton, Andrew J.; Sharif, Toqir; Coles, Simon J.; Hursthouse, Michael B.; Nyerges, Miklos; Anderson, Rosaleen J.; Bendell, David; McKillop, Alexander; Zhang, Weimin
Journal of the Chemical Society. Perkin Transactions 1, 2001 , # 21 p. 2781 - 2787
反应条件
phenyl silane; oxygen; bis(dipivaloylmethanato)manganese(II) in isopropyl alcohol
T=0°C; P=760 Torr; 15 h; Mechanism;
参考文献
Inoki, Satoshi; Kato, Koji; Isayama, Shigeru; Mukaiyama, Teruaki
Chemistry Letters, 1990 , # 10 p. 1869 - 1872
反应条件
[Ni(2,2'-bipyridine)3(2+)][BF4(1-)]2; tetrabutylammomium bromide; zinc dibromide in N,N-dimethyl-formamide
Ambient temperatureelectrolysis (carbon fiber cathode, zinc rod anode);
参考文献
Conan, Annie; Sibille, Soline; Perichon, Jacques
Journal of Organic Chemistry, 1991 , vol. 56, # 6 p. 2018 - 2024
反应条件
in tetrahydrofuran
T=20°C; Reformatsky Reaction; 72 h; Concentration;
参考文献
Mineno, Masahiro; Sawai, Yasuhiro; Kanno, Kazuaki; Sawada, Naotaka; Mizufune, Hideya
Journal of Organic Chemistry, 2013 , vol. 78, # 12 p. 5843 - 5850
反应条件
(i) Li, naphthalene, THF, (ii) /BRN= 1238185/, (iii) /BRN= 1718733/; Multistep reaction;
参考文献
Watanabe,S. et al.
Israel Journal of Chemistry, 1970 , vol. 8, p. 731 - 736
反应条件
1: lithium aluminium hydride / diethyl ether / 14 h / 0 °C
2: pyridine / 17 h / Ambient temperature
3: 86 percent / thionyl chloride / pyridine / 19 h / 0 °C
4: 4 percent / manganese(III) acetate dihydrate, acetic anhydride / acetic acid / 10 h / Heating
View Scheme
参考文献
Heilmann; Glenat
Bulletin de la Societe Chimique de France, 1955 , p. 1586,1590
反应条件
chloro-trimethyl-silane; lithium bromide in acetonitrile
T=20°C;
参考文献
Suri, Suresh C.; Marcischak, Jacob C.
Synthetic Communications, 2005 , vol. 35, # 3 p. 379 - 387
