1,3-二甲基-1H-吡唑-4-羧酸乙酯合成路线 （共 23 条）
反应条件
hydrogen; sodium acetate; palladium on activated charcoal in ethanol P=1520 Torr; Ambient temperature;
参考文献
Huppatz
Australian Journal of Chemistry, 1983 , vol. 36, # 1 p. 135 - 147
反应条件
5 palladium on charcoal; hydrogen; trioctylmethylammonium chloride; potassium carbonate; cesium fluoride in tetrahydrofuran T=110°C; pH=11; 20 h; Autoclave; Reagent/catalyst;
参考文献
EP2687514 A1, ;
Paragraph 0049; 0050 ;
反应条件
1: methylhydrazine; formic acid ethyl ester in ethanol T=0°C; Vilsmeier type formylation; 4 h; Reflux; 2: ethyl acetoacetate in ethanol 4 h; Reflux; 3: With sodium ethanolate in ethanol Knoevenagel type condensation; 0.75 h; Reflux; regioselective reaction;
参考文献
Tetrahedron Letters, , vol. 50, # 6 p. 696 - 699
反应条件
1: methylhydrazine; formic acid ethyl ester in ethanol T=0°C; Vilsmeier type formylation; 4 h; Reflux; 2: tetrolic acid ethyl ester in ethanol Reflux; 3: With sodium ethanolate in ethanol Knoevenagel type condensation; Reflux; regioselective reaction;
参考文献
Raw, Steven A.; Turner, Andrew T.
Tetrahedron Letters, 2009 , vol. 50, # 6 p. 696 - 699
反应条件
2,2,2-trifluoroethanol T=20°C; 0.166667 h; regioselective reaction;
参考文献
Journal of Fluorine Chemistry, , vol. 132, # 11 p. 995 - 1000
反应条件
1: 72 percent / triethylamine / benzene 2: 29 percent / phosphoryl chloride / 2 h / Heating 3: 92 percent / NaOH / ethanol; H2O / 2 h / Heating 4: 70 percent / conc. H2SO4 / 48 h / Heating 5: 93 percent / anhydrous sodium acetate, H2 / 5percent Pd/C / ethanol / 1520 Torr / Ambient temperature View Scheme
参考文献
Australian Journal of Chemistry, , vol. 36, # 1 p. 135 - 147
反应条件
1: 29 percent / phosphoryl chloride / 2 h / Heating 2: 92 percent / NaOH / ethanol; H2O / 2 h / Heating 3: 70 percent / conc. H2SO4 / 48 h / Heating 4: 93 percent / anhydrous sodium acetate, H2 / 5percent Pd/C / ethanol / 1520 Torr / Ambient temperature View Scheme
参考文献
Australian Journal of Chemistry, , vol. 36, # 1 p. 135 - 147
反应条件
1: 92 percent / NaOH / ethanol; H2O / 2 h / Heating 2: 70 percent / conc. H2SO4 / 48 h / Heating 3: 93 percent / anhydrous sodium acetate, H2 / 5percent Pd/C / ethanol / 1520 Torr / Ambient temperature View Scheme
参考文献
Australian Journal of Chemistry, , vol. 36, # 1 p. 135 - 147
反应条件
1: 94 percent / sodium carbonate, KMnO4 / H2O / 1 h / 60 °C 2: 70 percent / conc. H2SO4 / 48 h / Heating 3: 93 percent / anhydrous sodium acetate, H2 / 5percent Pd/C / ethanol / 1520 Torr / Ambient temperature View Scheme
参考文献
Australian Journal of Chemistry, , vol. 36, # 1 p. 135 - 147
反应条件
1: 70 percent / conc. H2SO4 / 48 h / Heating 2: 93 percent / anhydrous sodium acetate, H2 / 5percent Pd/C / ethanol / 1520 Torr / Ambient temperature View Scheme
参考文献
Australian Journal of Chemistry, , vol. 36, # 1 p. 135 - 147
