7,8-二甲氧基-3-(3-氯丙基)-1,3-二氢-2H-3-苯并氮杂卓-2-酮合成路线 （共 12 条）
反应条件
in dimethyl sulfoxide; acetone
反应条件
in dimethyl sulfoxide; acetone
反应条件
1: 81 percent / thionyl chloride / CH2Cl2 / 1 h / Heating 2: triethylamine / CH2Cl2 / 1 h / Ambient temperature 3: 75 percent / glacial acetic acid, conc. HCl / 17 h / Ambient temperature 4: 1.) potassium tert-butoxide / 1.) DMSO, RT, 30 min, 2.) RT, 30 min View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 33, # 5 p. 1496 - 1504
反应条件
1: triethylamine / CH2Cl2 / 1 h / Ambient temperature 2: 75 percent / glacial acetic acid, conc. HCl / 17 h / Ambient temperature 3: 1.) potassium tert-butoxide / 1.) DMSO, RT, 30 min, 2.) RT, 30 min View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 33, # 5 p. 1496 - 1504
反应条件
1: 75 percent / glacial acetic acid, conc. HCl / 17 h / Ambient temperature 2: 1.) potassium tert-butoxide / 1.) DMSO, RT, 30 min, 2.) RT, 30 min View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 33, # 5 p. 1496 - 1504
反应条件
1: sodium iodide / acetone / 20 h / 55 - 58 °C 2: potassium carbonate / acetone / 3 h / 55 - 58 °C 3: acetic acid; palladium(II) oxide hydrate; hydrogen / 3 h / 25 - 30 °C / 2250.23 - 3000.3 Torr View Scheme
参考文献
GLENMARK PHARMACEUTICALS LIMITED; GLENMARK GENERICS LIMITED; BHIRUD, Shekhar Bhaskar; BHUSHAN, Kumar Hari; ZOPE, Sunil Sudhakar; PATIL, Dipak Vinayak; DHEBADE, Pramod Amrutrao; CHAND, Prem
Patent: WO2014/102827 A1, 2014 ;
反应条件
sodium iodide in acetone 12 h; Heating;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 11, # 17 p. 2351 - 2354
反应条件
1: sodium iodide / acetone / 20 h / 55 - 58 °C
2: potassium carbonate / acetone / 3 h / 55 - 58 °C
View Scheme
参考文献
BIOCON LIMITED; KOTHAKONDA, Kiran Kumar; RAMASAMY, Sivakumar; BANDARU, Sravan Kumar; VENKATA, Srinivas Pullela
Patent: WO2014/20534 A1, 2014 ;
反应条件
hydrogen; acetic acid; palladium on activated charcoal
T=50°C; P=3750.3 Torr; 6 h;
参考文献
Bomhard, Andreas; Reiffen, Manfred; Heider, Joachim; Psiorz, Manfred; Lillie, Christian
Journal of Medicinal Chemistry, 1991 , vol. 34, # 3 p. 942 - 947
