6-甲氧基-2-吡啶甲腈合成路线 （共 15 条）
反应条件
triethylamine; trifluoroacetic anhydride in tetrahydrofuran T=0 - 20°C;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH and CO. KG
Patent: WO2009/70485 A1, 2009 ;
Location in patent: Page/Page column 105 ;
WO 2009/070485 A1
反应条件
in N,N-dimethyl-formamide 48 h; Heating;
参考文献
Bowman; Bridge; Brookes; Cloonan; Leach
Journal of the Chemical Society. Perkin Transactions 1, 2002 , vol. 2, # 1 p. 58 - 68
反应条件
N,N,N',N,-tetramethylethylenediamine; 1,5-bis-(diphenylphosphino)-pentane; palladium diacetate in toluene T=160°C; 16 h;
参考文献
Sundermeier, Mark; Zapf, Alexander; Mutyala, Sateesh; Baumann, Wolfgang; Sans, Juergen; Weiss, Stefan; Beller, Matthias
Chemistry - A European Journal, 2003 , vol. 9, # 8 p. 1828 - 1836
反应条件
in N,N-dimethyl-formamide T=20 - 100°C; 16 h;
参考文献
ENVIVO PHARMACEUTICALS, INC.; RIPKA, Amy; SHAPIRO, Gideon; MCRINER, Andrew, J.; BURSAVICH, Matthew, Gregory
Patent: WO2013/142269 A1, 2013 ;
Location in patent: Paragraph 0523; 0524 ;
反应条件
palladium diacetate; triphenylphosphine on polystyrene in N,N-dimethyl-formamide T=140°C; 0.5 h; Irradiationmicrowave;
参考文献
Srivastava, Rajiv R.; Collibee, Scott E.
Tetrahedron Letters, 2004 , vol. 45, # 48 p. 8895 - 8897
反应条件
1: 2-methoxy-pyridine With n-butyllithium; 2-(dimethylamino)-ethanol in hexane T=0°C; 1 h; 2: p-toluenesulphonyl cyanide in tetrahydrofuran T=0 - 20°C; 2 h; Further stages.;
参考文献
Bowman; Bridge; Brookes; Cloonan; Leach
Journal of the Chemical Society. Perkin Transactions 1, 2002 , vol. 2, # 1 p. 58 - 68
反应条件
1.1: 73 percent / sodium methoxide / 25 h / 62 °C 2.1: dimethylformamide / 48 h / 150 °C 2.2: 62 percent / FeCl3*6H2O; aq. HCl / dimethylformamide / 0.42 h / 80 °C View Scheme
参考文献
Journal of the Chemical Society. Perkin Transactions 1, , vol. 2, # 1 p. 58 - 68
反应条件
triethylamine in acetonitrile Heating;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 33, # 2 p. 565 - 571
反应条件
sulfuric acid 24 h; Irradiation;
参考文献
Bulletin of the Chemical Society of Japan, , vol. 55, # 9 p. 2906 - 2910
反应条件
sulfuric acid 1 h; Irradiationother alcohol, var. acid, var. acid conc., var. quenchers, var. substrate conc., var. additives; Product distributionMechanism;
参考文献
Bulletin of the Chemical Society of Japan, , vol. 55, # 9 p. 2906 - 2910
