乙基3-[4-(三氟甲基)苯基]丙酸酯合成路线 （共 11 条）
反应条件
diisobutylaluminium hydride; magnesium sulfate in toluene
参考文献
Chisso Corporation
Patent: US6235355 B1, 2001 ;
反应条件
manganese; water; trifluoroacetic acid; Co(2,2'-bipyridine)Br2; lithium bromide in pyridine; N,N-dimethyl-formamide
T=80°C;
参考文献
Amatore, Muriel; Gosmini, Corinne; Perichon, Jacques
Journal of Organic Chemistry, 2006 , vol. 71, # 16 p. 6130 - 6134
反应条件
palladium monocarbide in ethylene glycol dimethyl ether; ethanol; water
参考文献
Chisso Corporation
Patent: US6235355 B1, 2001 ;
反应条件
manganese; water; trifluoroacetic acid; Co(2,2'-bipyridine)Br2; lithium bromide in pyridine; N,N-dimethyl-formamide
T=50°C;
参考文献
Amatore, Muriel; Gosmini, Corinne; Perichon, Jacques
Journal of Organic Chemistry, 2006 , vol. 71, # 16 p. 6130 - 6134
反应条件
pyridine; [2,2']bipyridinyl; manganese; trifluoroacetic acid; cobalt(II) dibromide in N,N-dimethyl-formamide
T=50°C; 2 h;
参考文献
Amatore, Muriel; Gosmini, Corinne
Chemistry - A European Journal, 2010 , vol. 16, # 20 p. 5848 - 5852
反应条件
hydrogen; platinum(IV) oxide in ethanol
参考文献
Orr; Musso; Boswell; Kelley; Joyner; Davis; Baccanari
Journal of Medicinal Chemistry, 1995 , vol. 38, # 19 p. 3850 - 3856
反应条件
potassium carbonate; Pd-Tedicyp catalyst in N,N-dimethyl-formamide
T=110°C; Heck reaction; 20 h;
参考文献
Lemhadri, Mhamed; Doucet, Henri; Santelli, Maurice
Tetrahedron, 2004 , vol. 60, # 50 p. 11533 - 11540
反应条件
1: HCl / diethyl ether / Heating
2: H2 / PtO2 / ethanol
View Scheme
参考文献
Orr; Musso; Boswell; Kelley; Joyner; Davis; Baccanari
Journal of Medicinal Chemistry, 1995 , vol. 38, # 19 p. 3850 - 3856
反应条件
pyrrolidine; potassium hydroxide; tris(triphenylphosphine)ruthenium(II) chloride; isopropyl alcohol in toluene
24 h; Inert atmosphereReflux;
参考文献
Pridmore, Simon J.; Williams, Jonathan M.J.
Tetrahedron Letters, 2008 , vol. 49, # 52 p. 7413 - 7415
反应条件
1: C70H40Cl2F68N2O6Pd2; potassium chloride; tetra-n-butylammonium acetate; potassium carbonate / N,N-dimethyl acetamide / 0.17 h / 120 °C
2: hydrogenchloride; potassium chloride; tetra-n-butylammonium acetate; potassium carbonate / N,N-dimethyl acetamide; water / 0.17 h / 20 °C
View Scheme
参考文献
Susanto, Woen; Chu, Chi-Yuan; Ang, Wei Jie; Chou, Tzyy-Chao; Lo, Lee-Chiang; Lam, Yulin
Journal of Organic Chemistry, 2012 , vol. 77, # 6 p. 2729 - 2742
