N-[1-(S)-乙氧羰基-3-苯丙基]-L-丙氨酸合成路线 （共 47 条）
反应条件
1: 45 percent / methanol; H2O / 8 h / 70 °C 2: 99.3 percent / NH4Cl / aq. NH3 / 50 h / 37 °C / enzymatic hydrolysis with Pseudomonas putida at pH 9 3: 1.) NaNO2, 2N H2SO4; 2.) KBr, NaNO2, 3N H2SO4 / 1.) 50percent CH3COOH, r.t., 24 h; 2.) 50percent CH3COOH, 0-5 deg C, 1 h 4: 95 percent / SOCl2 / 24 h / Ambient temperature 5: H2O; nitromethane / 72 h / 50 °C / examined various solvent-base systems 6: 90 percent / CF3COOH / 2 h / Ambient temperature View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 37, # 2 p. 280 - 283
反应条件
1: 99.3 percent / NH4Cl / aq. NH3 / 50 h / 37 °C / enzymatic hydrolysis with Pseudomonas putida at pH 9 2: 1.) NaNO2, 2N H2SO4; 2.) KBr, NaNO2, 3N H2SO4 / 1.) 50percent CH3COOH, r.t., 24 h; 2.) 50percent CH3COOH, 0-5 deg C, 1 h 3: 95 percent / SOCl2 / 24 h / Ambient temperature 4: H2O; nitromethane / 72 h / 50 °C / examined various solvent-base systems 5: 90 percent / CF3COOH / 2 h / Ambient temperature View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 37, # 2 p. 280 - 283
反应条件
1: 95 percent / SOCl2 / 24 h / Ambient temperature 2: H2O; nitromethane / 72 h / 50 °C / examined various solvent-base systems 3: 90 percent / CF3COOH / 2 h / Ambient temperature View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 37, # 2 p. 280 - 283
反应条件
1: H2O; nitromethane / 72 h / 50 °C / examined various solvent-base systems 2: 90 percent / CF3COOH / 2 h / Ambient temperature View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 37, # 2 p. 280 - 283
反应条件
1: 1.) NaNO2, 2N H2SO4; 2.) KBr, NaNO2, 3N H2SO4 / 1.) 50percent CH3COOH, r.t., 24 h; 2.) 50percent CH3COOH, 0-5 deg C, 1 h 2: 95 percent / SOCl2 / 24 h / Ambient temperature 3: H2O; nitromethane / 72 h / 50 °C / examined various solvent-base systems 4: 90 percent / CF3COOH / 2 h / Ambient temperature View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 37, # 2 p. 280 - 283
反应条件
1: in water; ethyl acetate T=19 - 20°C; pH=10 - 11; 5 h; 2: T=30°C; pH=4.3 - 4.7; 0.166667 h;
参考文献
US6335453 B1, ;
Example 1 ;
反应条件
formic acid; tributyl-amine; palladium on activated charcoal 1.) CH2Cl2, -20 deg C, 2 h, 2.) methanol, 2 h; Yield given. Multistep reaction;
参考文献
Archiv der Pharmazie, , vol. 327, # 11 p. 739 - 742
反应条件
T=80°C; 17 h; Acidic conditions; Kinetics; Time;
参考文献
International Journal of Pharmaceutics, , vol. 438, # 1-2 p. 61 - 70
反应条件
1: 1->3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride / dimethylformamide / 18 h / Ambient temperature 2: 4.6 g / NEt3 / dimethylformamide / Ambient temperature 3: 0.4 g / conc. aq. HCl / acetonitrile / 10 h / 5 °C View Scheme
参考文献
Smith, Elizabeth M.; Swiss, Gerald F.; Neustadt, Bernard R.; McNamara, Paul; Gold, Elijah H.; et al.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 7 p. 1600 - 1606
反应条件
benzotriazol-1-ol; triethylamine in dichloromethane T=25 - 30°C; 16 h;
参考文献
IPCA LABORATORIES LIMITED
Patent: WO2009/122433 A2, 2009 ;
Location in patent: Page/Page column 13 ;
