2-(羟基亚甲基)环己酮合成路线 （共 42 条）
反应条件
1: 88 percent / AcONa / H2O; methanol
2: 90 percent / CH3COOH, CF3COOH / 3 h / Heating
3: 1.) NaH / 1.) DMF, from 0 to 5 deg C, 1 h, 2.) DMF, a) from 0 to 5 deg C, 3 h, b) RT, 12 h
View Scheme
参考文献
Wu, Zhijie; Li, Ying; Cai, Yu; Yuan, Junying; Yuan, Chengye
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 17 p. 4903 - 4906
反应条件
triethylamine in diethyl ether
参考文献
Tius, Marcus A.; Gomez-Galeno, Jorge
Tetrahedron Letters, 1986 , vol. 27, # 23 p. 2571 - 2574
反应条件
potassium carbonate in acetone
14 h; Heating;
参考文献
Brady, William T.; Agho, Michael O.
Journal of Organic Chemistry, 1983 , vol. 48, # 26 p. 5337 - 5341
反应条件
1: 74 percent / K2CO3 / acetone / 14 h / Heating
2: 68 percent / Et3N / hexane / 2.5 h / Heating
View Scheme
参考文献
Brady, William T.; Agho, Michael O.
Journal of Organic Chemistry, 1983 , vol. 48, # 26 p. 5337 - 5341
反应条件
1: 74 percent / K2CO3 / acetone / 14 h / Heating
2: Et3N / hexane / 2.5 h / Heating
3: Zn, acetic acid / H2O / 24 h / Ambient temperature
View Scheme
参考文献
Brady, William T.; Agho, Michael O.
Journal of Organic Chemistry, 1983 , vol. 48, # 26 p. 5337 - 5341
反应条件
1: 74 percent / K2CO3 / acetone / 14 h / Heating
2: 68 percent / Et3N / hexane / 2.5 h / Heating
3: Zn, acetic acid / H2O / 24 h / Ambient temperature
View Scheme
参考文献
Brady, William T.; Agho, Michael O.
Journal of Organic Chemistry, 1983 , vol. 48, # 26 p. 5337 - 5341
反应条件
lithium aluminium tetrahydride; diethyl ether
参考文献
Dreiding; Hartman
Journal of the American Chemical Society, 1953 , vol. 75, p. 939,940
参考文献
Torkelson,S.; Ainsworth,C.
Synthesis, 1976 , p. 722 - 724
反应条件
ethanol; triethylamine
参考文献
Burnett; Ainsworth
Journal of Organic Chemistry, 1958 , vol. 23, p. 1382
反应条件
hydrogenchloride in methanol; diethyl ether
参考文献
Zhungietu,G.I.; Sukhanyuk,B.P.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1972 , vol. 8, p. 932 - 934
Khimiya Geterotsiklicheskikh Soedinenii, 1972 , vol. 8, p. 1030 - 1032
