(R)-(-)-2-苯丙酸合成路线 （共 166 条）
反应条件
lithium hydroxide; dihydrogen peroxide in tetrahydrofuran; water T=20°C; 12 h;
参考文献
Tetrahedron Asymmetry, , vol. 17, # 24 p. 3386 - 3399
反应条件
Jacobsen's (R,R)-(salen)Co(III) catalyst; tetra-(n-butyl)ammonium iodide in N,N-dimethyl-formamide T=50°C; P=0.00750075 Torr; Electrolysis; Overall yield = 16 percent;
参考文献
Electrochemistry Communications, , vol. 42, p. 55 - 59
反应条件
Birman's catalyst; 4-methoxybenzoic anhydride; N-ethyl-N,N-diisopropylamine in dichloromethane T=20°C; 12 h; Resolution of racemate; optical yield given as percent ee;
参考文献
Shiina, Isamu; Nakata, Kenya
Patent: US2010/234610 A1, 2010 ;
Location in patent: Page/Page column 6-7 ;
反应条件
Jacobsen's (R,R)-(salen)Co(III) catalyst; tetra-(n-butyl)ammonium iodide in N,N-dimethyl-formamide T=50°C; P=0.00750075 Torr; Electrolysis; Temperature; Overall yield = 37 percent;
参考文献
Electrochemistry Communications, , vol. 42, p. 55 - 59
反应条件
hydrogen; Rult;(S)-2,2'-bis(diphenylphosphino)-1,1'-binaphthylgt;(OCOCH3)2 in methanol T=15 - 30°C; P=85120.1 Torr; 24 h; Title compound not separated from byproducts;
参考文献
Journal of Organic Chemistry, , vol. 52, # 14 p. 3174 - 3176
反应条件
4-methoxybenzoic anhydride; N-ethyl-N,N-diisopropylamine; Birman's catalyst in dichloromethane T=20°C; 12 h; Resolution of racemate;
参考文献
Shiina, Isamu; Nakata, Kenya
Patent: US2010/234610 A1, 2010 ;
Location in patent: Page/Page column 8-9 ;
反应条件
sodium periodate; ruthenium trichloride in tetrachloromethane; water; acetonitrile T=20°C; Sharpless oxidation; 1.5 h;
参考文献
Norinder, Jakob; Bogar, Krisztian; Kanupp, Lisa; Baeckvall, Jan-E.
Organic Letters, 2007 , vol. 9, # 24 p. 5095 - 5098
反应条件
[Pd2Cl2(μ-Cl)2((S)-μ-3,5-xyl-phanephos)]; water; toluene-4-sulfonic acid; lithium chloride in butanone T=50°C; P=22502.3 Torr; 42 h; Autoclave; optical yield given as percent eeenantioselective reaction;
参考文献
Angewandte Chemie - International Edition, , vol. 49, # 48 p. 9197 - 9200
反应条件
Birman's catalyst; benzoic acid anhydride; N-ethyl-N,N-diisopropylamine in dichloromethane T=20°C; 2.5 h; Inert atmosphereResolution of racemate; optical yield given as percent eeenantioselective reaction;
参考文献
Journal of the American Chemical Society, , vol. 132, # 33 p. 11629 - 11641
反应条件
4-methoxybenzoic anhydride; N-ethyl-N,N-diisopropylamine; Birman's catalyst in dichloromethane T=20°C; 4 h; Resolution of racemate;
参考文献
US2010/234610 A1, ;
Page/Page column 10-11 ;
