(5-氯-1-戊炔基)三甲基硅烷合成路线 （共 13 条）
反应条件
n-butyllithium 1.) THF, -20 degC, 2.) 15 min, 0 degC;
参考文献
Fournet; Balme; Gore
Tetrahedron, 1991 , vol. 47, # 32 p. 6293 - 6304
反应条件
zinc trifluoromethanesulfonate; triethylamine in dichloromethane T=23°C; 0.75 h;
参考文献
Rahaim Jr., Ronald J.; Shaw, Jared T.
Journal of Organic Chemistry, 2008 , vol. 73, # 7 p. 2912 - 2915
反应条件
n-butyllithium 1.) THF, hexane, -60 deg C then r.t., 30 min; 2.) THF, hexane, -78 deg C to r.t. within 12 h, r.t., 12 h; Yield given. Multistep reaction;
参考文献
Synthesis, , # 10 p. 998 - 1012
反应条件
1: trimethylsilylacetylene With n-butyllithium in tetrahydrofuran 2: 3-chloropropyl tosylate With tert-butylamine hydrobromide in tetrahydrofuran T=0 - 20°C;
参考文献
Schaefer, Carsten; Scholz, Gerald; Gleiter, Rolf; Oeser, Thomas; Rominger, Frank
European Journal of Inorganic Chemistry, 2005 , # 7 p. 1274 - 1281
反应条件
zinc in acetonitrile T=100°C; 12 h;
参考文献
Sugita, Hikaru; Hatanaka, Yasuo; Hiyama, Tamejiro
Chemistry Letters, 1996 , # 5 p. 379 - 380
反应条件
n-butyllithium 1.) THF, hexane, r.t., 30 min; 2.) THF, hexane, DMSO, 16 deg C, 1 h; Yield given. Multistep reaction;
参考文献
Synthesis, , # 10 p. 998 - 1012
反应条件
1: 1.) DIBAH, 2.) I2 / 1.) ether, 40 deg C, 2 h; 2.) ether, THF, -78 deg C 2: 67 percent Chromat. / n-BuLi / diethyl ether; pentane / -78 deg C, 30 min; up to 25 deg C over 1 h View Scheme
参考文献
Negishi,E.; Boardman,L.D.; Sawada,H.
Journal of the American Chemical Society, 1988 , vol. 110, p. 5383
反应条件
lithium diisopropyl amide in tetrahydrofuran; hexane -78 deg C to r.t.;
参考文献
Militzer; Schomenauer; Otte; Puls; Hain; Brase; De Meijere
Synthesis, 1993 , # 10 p. 998 - 1012
反应条件
sodium iodide in acetone 24 h; Heating;
参考文献
Brummond, Kay M.; McCabe, Jamie M.
Tetrahedron, 2006 , vol. 62, # 45 p. 10541 - 10554
反应条件
1.1: Mg; EtBr / diethyl ether / 3 h / Heating
1.2: 97 percent / Li2CuCl4 / diethyl ether; tetrahydrofuran / -78 - 20 °C
2.1: KF; KOH / methanol / 3 h / 40 °C
View Scheme
参考文献
Kel'in; Sromek; Gevorgyan
Journal of the American Chemical Society, 2001 , vol. 123, # 9 p. 2074 - 2075
