1-苯基-1-氰基环戊烷合成路线 （共 16 条）
反应条件
sodium hydride in diethyl ether; dimethyl sulfoxide; mineral oil T=0 - 20°C;
参考文献
US2014/38990 A1, ;
Paragraph 0211-0212 ;
反应条件
bis(η3-allyl-μ-chloropalladium(II)); 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene in 1,3,5-trimethyl-benzene T=20 - 140°C; 16.1667 h; Inert atmosphereSealed tube; chemoselective reaction;
参考文献
Angewandte Chemie - International Edition, , vol. 50, # 19 p. 4470 - 4474
反应条件
potassium carbonate T=177 - 205°C; Substitution; 17 h;
参考文献
Organic Preparations and Procedures International, , vol. 23, # 2 p. 153 - 156
反应条件
ammonia; sodium amide T=-30°C; anschliessend mit einer Loesung von 1.4-Dibrom-butan in Aether bei -50grad und Erwaermen des vom Ammoniak befreiten Reaktionsgemisches auf Siedetemperatur;
参考文献
Journal of the American Chemical Society, , vol. 69, p. 2902,2904
反应条件
1: potassium tert-butylate / ethanol; water / Inert atmosphere; Heating 2: bis(η3-allyl-μ-chloropalladium(II)); 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene / 1,3,5-trimethyl-benzene / 16.17 h / 20 - 140 °C / Inert atmosphere; Sealed tube View Scheme
参考文献
Angewandte Chemie - International Edition, , vol. 50, # 19 p. 4470 - 4474
反应条件
1.1: diisobutylaluminium hydride / dichloromethane; cyclohexane / 0.25 h / 0 °C 2.1: triphenylphosphine / dichloromethane / 0.5 h / 0 °C 2.2: 3 h / 0 °C 3.1: tert.-butyl lithium / tetrahydrofuran / -78 - 20 °C View Scheme
参考文献
Henrion, Guilhem; Chavas, Thomas E. J.; Le Goff, Xavier; Gagosz, Fabien
Angewandte Chemie - International Edition, 2013 , vol. 52, # 24 p. 6277 - 6282
Angew. Chem., 2013 , vol. 125, # 24 p. 6397 - 6402,6
反应条件
potassium hydroxide in ethanol 96 h; Heating;
参考文献
Roberts, Donald D.; Arant, Mark E.
Journal of Organic Chemistry, 1994 , vol. 59, # 21 p. 6464 - 6469
反应条件
methanol; ammonia; nickel T=120°C; P=73550.8 Torr; Hydrogenation;
参考文献
Trivedi, Bharat K.; Holmes, Ann; Stoeber, Terri L.; Blankley, C. John; Roark, W. Howard; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 22 p. 3300 - 3307
反应条件
(i) KOH, diethylene glycol, (ii) SOCl2, benzene; Multistep reaction;
参考文献
Bonnekessel,J.; Ruechardt,C.
Chemische Berichte, 1973 , vol. 106, p. 2890 - 2903
反应条件
1: H2SO4 2: Br2 / methanol 3: KOH / bis-(2-hydroxy-ethyl) ether View Scheme
参考文献
Bonnekessel,J.; Ruechardt,C.
Chemische Berichte, 1973 , vol. 106, p. 2890 - 2903
