2-氧代-1-吡咯烷PROPIONITRILE合成路线 （共 13 条）
反应条件
1: 76 percent / H2, AcOH / 10percent Pd/C / 48 h / 760 Torr / Ambient temperature 2: 73 percent / DIBAH / tetrahydrofuran; hexane / 1 h / Ambient temperature View Scheme
参考文献
Diker, Khalid; El Biach, Khalid; Doee De Maindreville, Michele; Levy, Jean
Journal of Natural Products, 1997 , vol. 60, # 8 p. 791 - 793
反应条件
toluene-4-sulfonic acid 20 h; Heating;
参考文献
Takahata; Okajima; Yamazaki
Chemical and Pharmaceutical Bulletin, 1980 , vol. 28, # 12 p. 3632 - 3638
反应条件
1: With sodium hydroxide; water in 1,4-dioxane 5 h; Heating / reflux; 2: With hydrogenchloride in 1,4-dioxane; water
参考文献
Agouron Pharmaceuticals, Inc.
Patent: US2005/176701 A1, 2005 ;
Location in patent: Page/Page column 22-23 ;
US 20050176701 A1
反应条件
ammonia; cobalt T=100°C; P=147102 Torr; Hydrogenation;
参考文献
Reppe et al.
Justus Liebigs Annalen der Chemie, 1955 , vol. 596, p. 1,211
反应条件
potassium hydroxide; tetrabutylammomium bromide in tetrahydrofuran
R.T., 1 h then reflux, 3 h;
参考文献
Takahata; Okajima; Yamazaki
Chemical and Pharmaceutical Bulletin, 1980 , vol. 28, # 12 p. 3632 - 3638
反应条件
1: 1-(2-hydroxy-ethyl)-2-pyrrolidone With triphenylphosphine; diethylazodicarboxylate in tetrahydrofuran; diethyl ether
T=-20°C; 0.5 h;
2: 2-hydroxy-2-methyl-propionitrile in tetrahydrofuran; diethyl ether
T=20°C; Further stages.;
参考文献
Bruno, Claudio; Catalano, Alessia; Desaphy, Jean-Francois; Cavalluzzi, Maria M.; Carocci, Alessia; Dipalma, Antonella; Franchini, Carlo; Lentini, Giovanni; Camerino, Diana Conte; Tortorella, Vincenzo
Heterocycles, 2007 , vol. 71, # 9 p. 2011 - 2026
反应条件
in N,N-dimethyl-formamide
T=50°C; 5 h;
参考文献
Bruno, Claudio; Catalano, Alessia; Desaphy, Jean-Francois; Cavalluzzi, Maria M.; Carocci, Alessia; Dipalma, Antonella; Franchini, Carlo; Lentini, Giovanni; Camerino, Diana Conte; Tortorella, Vincenzo
Heterocycles, 2007 , vol. 71, # 9 p. 2011 - 2026
参考文献
Reppe et al.
Justus Liebigs Annalen der Chemie, 1955 , vol. 596, p. 1,211
参考文献
Reppe et al.
Justus Liebigs Annalen der Chemie, 1955 , vol. 596, p. 1,211
参考文献
BASF
Patent: DE850747 , 1943 ;
