1-甲醛基 -4-甲基哌嗪合成路线 （共 16 条）
反应条件
acetic anhydride T=80 - 90°C; 1 h;
参考文献
Khromov-Borisov, N. V.; Aleksandrova, L. N.; Danilov, A. F.; Shelkovnikov, S. A.
Pharmaceutical Chemistry Journal, 1984 , vol. 18, # 6 p. 401 - 403
Khimiko-Farmatsevticheskii Zhurnal, 1984 , vol. 18, # 6 p. 689 - 691
反应条件
palladium/alumina; hydrogen in octane T=130°C; P=22502.3 Torr; 24 h; Autoclave; PressureReagent/catalystSolventTemperatureTime;
参考文献
Cui, Xinjiang; Zhang, Yan; Deng, Youquan; Shi, Feng
Chemical Communications, 2014 , vol. 50, # 2 p. 189 - 191
反应条件
[(C5Me5)IrI2]2 in water T=115°C; 10 h; Inert atmosphere;
参考文献
Saidi, Ourida; Bamford, Mark J.; Blacker, A. John; Lynch, James; Marsden, Stephen P.; Plucinski, Pawel; Watson, Robert J.; Williams, Jonathan M.J.
Tetrahedron Letters, 2010 , vol. 51, # 44 p. 5804 - 5806
反应条件
benzoic acid methyl ester T=200°C; 0.0833333 h; Microwave irradiation;
参考文献
Yang, Dongsik; Jeon, Heung Bae
Bulletin of the Korean Chemical Society, 2010 , vol. 31, # 5 p. 1424 - 1426
反应条件
in tetrahydrofuran T=20°C; 0.25 h; chemoselective reaction;
参考文献
Cochet, Thomas; Bellosta, Veronique; Greiner, Alfred; Roche, Didier; Cossy, Janine
Synlett, 2011 , # 13 p. 1920 - 1922
反应条件
sodium hydroxide; tetrabutyl ammonium fluoride T=50°C; 0.333333 h;
参考文献
Gol'dberg, Yu. Sh.; Shimanskaya, M. V.
Journal of Organic Chemistry USSR (English Translation), 1982 , vol. 18, # 10 p. 1789 - 1794
Zhurnal Organicheskoi Khimii, 1982 , vol. 18, # 10 p. 2036 - 2042
反应条件
1: 1-methyl-piperazine With formic acid 0.25 h; cooling; 2: benzaldehyde T=180 - 200°C; Leuckart-Wallach reaction; 8 h; Further stages.;
参考文献
Ignatovich; Gusak; Chernikhova; Kozlov; Koroleva
Chemistry of Heterocyclic Compounds, 2007 , vol. 43, # 12 p. 1540 - 1543
反应条件
1: 1-methyl-piperazine With formic acid 0.25 h; cooling; 2: 4-formylbenzoic acid methyl ester T=180 - 200°C; Leuckart-Wallach reaction; 8 h; Further stages.;
参考文献
Ignatovich; Gusak; Chernikhova; Kozlov; Koroleva
Chemistry of Heterocyclic Compounds, 2007 , vol. 43, # 12 p. 1540 - 1543
反应条件
sodium carbonate T=160°C; 24 h;
参考文献
Tetrahedron Letters, , vol. 46, # 1 p. 153 - 156
反应条件
1: 1-methyl-piperazine With formic acid 0.25 h; cooling; 2: 4-nitrobenzaldehdye T=180 - 200°C; Leuckart-Wallach reaction; 8 h; Further stages.;
参考文献
Ignatovich; Gusak; Chernikhova; Kozlov; Koroleva
Chemistry of Heterocyclic Compounds, 2007 , vol. 43, # 12 p. 1540 - 1543
