5-乙烯基-2-吡咯烷酮合成路线 （共 11 条）
反应条件
1: pyrrolidin-1-yl-2,5-dione With sodium tetrahydroborate in ethanol T=5°C; 0.0333333 h; Inert atmosphere; 2: With hydrogenchloride in ethanol T=-5°C; 5.5 h; 3: vinyl-magnesium chloride
参考文献
Targeon SAS
Patent: EP2537827 A1, 2012 ;
Location in patent: Page/Page column 9-10 ;
反应条件
1: in tetrahydrofuran T=0°C; 3 h; Inert atmosphereReflux; 2: With ammonium chloride in tetrahydrofuran Inert atmosphere; Product distribution / selectivity;
参考文献
Targeon SAS
Patent: EP2537827 A1, 2012 ;
Location in patent: Page/Page column 7-8 ;
反应条件
1: in tetrahydrofuran T=0°C; 3 h; Inert atmosphereReflux; 2: With ammonium chloride in tetrahydrofuran Inert atmosphere; Product distribution / selectivity;
参考文献
Targeon SAS
Patent: EP2537827 A1, 2012 ;
Location in patent: Page/Page column 7-8 ;
参考文献
Silverman; Bichler; Leon
Journal of the American Chemical Society, 1996 , vol. 118, # 6 p. 1241 - 1252
反应条件
1: 2-oxo-5-ethoxy pyrrolidine With ethyl magnesium chloride in tetrahydrofuran T=-15°C; 0.5 h; Inert atmosphere; 2: vinyl-magnesium chloride in tetrahydrofuran 2 h; RefluxInert atmosphere; 3: With ammonium chloride in tetrahydrofuran T=20°C; Inert atmosphere; Product distribution / selectivity;
参考文献
EP2537827 A1, ;
Page/Page column 8-9 ;
参考文献
BASF Aktiengesellschaft
Patent: US5496958 A1, 1996 ;
反应条件
in tetrahydrofuran 2 h; Heating; Yield given;
参考文献
Tetrahedron Letters, , vol. 31, # 47 p. 6923 - 6926
反应条件
1: 1.) N-bromosuccinimide, HF, pyridine, 2.) t-BuOK / 1.) ether, RT, 2 h, 2.) THF, from -30 deg C to -20 deg C, 2 h 2: 33 percent / 1 N aq. HCl / 19 h / 85 °C View Scheme
参考文献
Silverman; Bichler; Leon
Journal of the American Chemical Society, 1996 , vol. 118, # 6 p. 1241 - 1252
反应条件
1: With water; potassium hydroxide in isopropyl alcohol T=20 - 60°C; 16 h; Inert atmosphere; 2: With acetic acid in water; isopropyl alcohol
参考文献
Targeon SAS
Patent: EP2537827 A1, 2012 ;
Location in patent: Page/Page column 9 ;
反应条件
1: 34 percent / benzene / 24 h / Heating
2: 83 percent / Ba(OH)2*H2O / H2O; propan-2-ol / 12 h / Heating
View Scheme
参考文献
Wei, Z. Y.; Knaus, Edward E.
Organic Preparations and Procedures International, 1994 , vol. 26, # 5 p. 567 - 570
