1,1,2-乙烷三甲酸三乙酯合成路线 （共 41 条）
反应条件
1: diethyl malonate With sodium in ethanol 0.5 h; 2: chloroacetic acid ethyl ester in ethanol T=15°C; 6.5 h; Reflux;
参考文献
SAUDI BASIC INDUSTRIES CORPORATION; SABIC PETROCHEMICAL B.V.; SAINANI, Jaiprakash Brijlal; DAVADRA, Mahesh
Patent: WO2013/29767 A1, 2013 ;
Location in patent: Page/Page column 16; 17 ;
反应条件
potassium hydroxide; N-benzyl-N,N,N-triethylammonium chloride in N,N-dimethyl-formamide T=35 - 40°C;
参考文献
Sizov, A. Yu.; Dombrovskii, V. A.; Yanovskaya, L. A.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1991 , vol. 40, # 5.1 p. 955 - 961
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1991 , # 5 p. 1073 - 1079
反应条件
1: diethyl malonate With sodium hydride in tetrahydrofuran T=0 - 20°C; 2.5 h; 2: ethyl bromoacetate in tetrahydrofuran T=0 - 20°C; 3 h;
参考文献
MEDIVIR AB
Patent: WO2005/65689 A1, 2005 ;
Location in patent: Page/Page column 39-40 ;
反应条件
1: diethyl malonate With sodium ethanolate in ethanol 0.166667 h; 2: chloroacetic acid ethyl ester in ethanol 4 h; Heating / reflux;
参考文献
WO2007/106561 A2, ;
Page/Page column 67-68 ;
反应条件
NaH in N,N-dimethyl-formamide
反应条件
in diethyl ether T=-70 - -40°C; 1 h;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 34, # 6 p. 2417 - 2427
反应条件
sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate in dichloromethane; water
参考文献
Sakai, Takashi; Yoshida, Masanori; Kohmoto, Shoichi; Utaka, Masanori; Takeda, Akira
Tetrahedron Letters, 1982 , vol. 23, # 49 p. 5185 - 5188
参考文献
Dutt; Karmakar
Synthesis, 1981 , vol. No.10, p. 826 - 828
反应条件
potassium ethanolate in diethyl ether
参考文献
Journal of the Chemical Society [Section] C: Organic, , vol. <C>, p. 893 - 900
参考文献
Annales de Chimie (Cachan, France), , vol. <6>27, p. 247
Zhurnal Russkago Fiziko-Khimicheskago Obshchestva, , vol. 9, p. 278
Chemische Berichte, , vol. 9, p. 1604
Annales de Chimie (Cachan, France), , vol. <6>18, p. 284
Bulletin de la Societe Chimique de France, , vol. <3>1, p. 300
