4-氟-4-甲基-1,1-联苯合成路线 （共 47 条）
反应条件
dipotassium hydrogenphosphate in water; dimethyl sulfoxide pH=7; 72 h; Microbiological reaction;
参考文献
Bright, Tara V.; Dalton, Fay; Elder, Victoria L.; Murphy, Cormac D.; O'Connor, Neil K.; Sandford, Graham
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 7 p. 1135 - 1142
反应条件
potassium fluoride; [Ph2P(CH2)2NH2]2PdCl2 in tetrahydrofuran; water
T=25 - 27°C; Suzuki cross-coupling reaction; 6 h;
参考文献
Li, Jin-Heng; Hu, Xi-Chao; Xie, Ye-Xiang
Tetrahedron Letters, 2006 , vol. 47, # 52 p. 9239 - 9243
反应条件
tetra-n-butylammonium acetate; polyurea-encapsulated Pd(OAc)2 in various solvent(s)
T=100°C; Suzuki reaction;
参考文献
Ley, Steven V.; Ramarao, Chandrashekar; Gordon, Richard S.; Holmes, Andrew B.; Morrison, Angus J.; McConvey; Shirley, Ian M.; Smith, Stephen C.; Smith, Martin D.
Chemical Communications, 2002 , # 10 p. 1134 - 1135
反应条件
potassium carbonate; polymer-supported Pd catalyst FC 1032 in ethanol
T=120°C; Suzuki coupling; 0.166667 h; microwave irradiation;
参考文献
Wang, Ying; Sauer, Daryl R.
Organic Letters, 2004 , vol. 6, # 16 p. 2793 - 2796
反应条件
1: triallyl(4-fluorophenyl)silane With tetrabutyl ammonium fluoride in tetrahydrofuran; water
T=20°C; 1 h;
2: 4-methyl-chlorobenzene With 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl; bis(η3-allyl-μ-chloropalladium(II)) in tetrahydrofuran; water
T=80°C; 11 h;
参考文献
Sahoo, Akhila K.; Nakao, Yoshiaki; Hiyama, Tamejiro
Chemistry Letters, 2004 , vol. 33, # 5 p. 632 - 633
反应条件
Ph3PAuOTs; [bis(acetoxy)iodo]benzene; camphor-10-sulfonic acid in methanol; chloroform
T=20°C;
参考文献
Ball, Liam T.; Lloyd-Jones, Guy C.; Russell, Christopher A.
Science (Washington, DC, United States), 2012 , vol. 337, # 6102 p. 1644 - 1648,5
反应条件
(S,R)-t-Bu-Josiphos; bis(dibenzylideneacetone)-palladium(0) in tetrahydrofuran; toluene
T=25°C; 5 h;
参考文献
Roy, Amy H.; Hartwig, John F.
Journal of the American Chemical Society, 2003 , vol. 125, # 29 p. 8704 - 8705
反应条件
N-ethyl-N,N-diisopropylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct in water; isopropyl alcohol
T=100°C; Suzuki coupling; 0.166667 h; microwave irradiation;
参考文献
Kabalka, George W.; Al-Masum, Mohammad
Tetrahedron Letters, 2005 , vol. 46, # 37 p. 6329 - 6331
反应条件
lithium tert-butylate; [NiCl2(PMe3)2] in tetrahydrofuran
T=60°C; 2 h;
参考文献
Miller, Joseph A.
Tetrahedron Letters, 2001 , vol. 42, # 40 p. 6991 - 6993
反应条件
potassium phosphate; tetrakis(triphenylphosphine) palladium(0) in 1,4-dioxane
T=90°C; Suzuki-Miyaura coupling;
参考文献
Huang, Yangen; Chen, Dajun; Qing, Feng-Ling
Synlett, 2005 , # 11 art. no. U11805ST, p. 1740 - 1742
