4-氨基-3-溴苯甲酸乙酯合成路线 （共 12 条）
反应条件
N-bromosuccinmide in chloroform T=5 - 10°C; 4 h;
参考文献
Tobe, Yoshito; Utsumi, Naoto; Kawabata, Kazuya; Nagano, Atsushi; Adachi, Kiyomi; Araki, Shunji; Sonoda, Motohiro; Hirose, Keiji; Naemura, Koichiro
Journal of the American Chemical Society, 2002 , vol. 124, # 19 p. 5350 - 5364
反应条件
1: N-bromosuccinimide / CCl4 / 5 h / 80 °C 2: CH3OH / 0.02 h View Scheme
参考文献
Synthesis, , # 4 p. 263 - 264
参考文献
Chemicke Listy, , vol. 31, p. 460,461, 463
Chem. Zentralbl., , vol. 109, # I p. 3193
反应条件
1: With tert.-butylnitrite; boron trifluoride diethyl etherate in dichloromethane T=-10 - 20°C; 4 h; 2: With sodium cyanide; copper (I) cyanide in toluene T=0 - 60°C; 1.5 h;
参考文献
US2005/282825 A1, ;
Page/Page column 8 ;
US 20050282825 A1
反应条件
1: 4-amino-3-methoxy-benzoic acid ethyl ester With tert.-butylnitrite; boron trifluoride diethyl etherate in dichloromethane 2: copper (I) cyanide With sodium cyanide in water; toluene
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 1 p. 153 - 158
反应条件
1: 94 percent / ICl / acetic acid; H2O / 10 h / 80 °C 2: 88 percent / NaNO2; H2SO4 / benzene; ethanol / 1.5 h / Heating View Scheme
参考文献
Tobe, Yoshito; Utsumi, Naoto; Kawabata, Kazuya; Naemura, Koichiro
Tetrahedron Letters, 1996 , vol. 37, # 52 p. 9325 - 9328
反应条件
hydrogenchloride in ethyl acetate
参考文献
Takeda Pharmaceutical Company Limited
Patent: EP1726580 A1, 2006 ;
Location in patent: Page/Page column 120 ;
EP 1726580 A1
反应条件
sulfuric acid; dihydrogen peroxide in acetic acid
T=80°C; 17 h;
参考文献
Decodts; Wakselman
European Journal of Medicinal Chemistry, 1983 , vol. 18, # 2 p. 107 - 111
反应条件
sulfuryl dichloride; acetic acid
T=40 - 45°C; 2 h;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH and CO. KG
Patent: WO2006/100009 A1, 2006 ;
Location in patent: Page/Page column 135-136 ;
WO 2006/100009 A1
反应条件
1.1: BF3*Et2O; t-BuONO / CH2Cl2
1.2: 48 percent / NaCN / toluene; H2O
2.1: 74 percent / DIBAL / CH2Cl2 / -100 °C
View Scheme
参考文献
Wang, Gary T.; Wang, Xilu; Wang, Weibo; Hasvold, Lisa A.; Sullivan, Gerry; Hutchins, Charles W.; O'Conner, Steve; Gentiles, Robert; Sowin, Thomas; Cohen, Jerry; Gu, Wen-Zhen; Zhang, Haiying; Rosenberg, Saul H.; Sham, Hing L.
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 1 p. 153 - 158
