(2-甲氧基-5-甲基苯基)乙腈合成路线 （共 8 条）
反应条件
sodium cyanide; sodium iodide in acetone
15 h; Heating;
参考文献
Dijkstra, Pieter J.; Skowronska-Ptasinska, Maria; Reinhoudt, David N.; Hertog, Herman J. den; Eerden, Johan van; et al.
Journal of Organic Chemistry, 1987 , vol. 52, # 22 p. 4913 - 4921
反应条件
potassium iodide in dimethyl sulfoxide
20 h; Ambient temperature;
参考文献
Langlois, Michel; Bremont, Beatrice; Shen, Shuren; Poncet, Annie; Andrieux, Jean; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 12 p. 2050 - 2060
反应条件
1: 87 percent / LiAlH4 / tetrahydrofuran / 20 h / Heating
2: 69 percent / thionyl chloride, pyridine / toluene / 24 h / Ambient temperature
3: 91 percent / KI / dimethylsulfoxide / 20 h / Ambient temperature
View Scheme
参考文献
Langlois, Michel; Bremont, Beatrice; Shen, Shuren; Poncet, Annie; Andrieux, Jean; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 12 p. 2050 - 2060
反应条件
1: 69 percent / thionyl chloride, pyridine / toluene / 24 h / Ambient temperature
2: 91 percent / KI / dimethylsulfoxide / 20 h / Ambient temperature
View Scheme
参考文献
Langlois, Michel; Bremont, Beatrice; Shen, Shuren; Poncet, Annie; Andrieux, Jean; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 12 p. 2050 - 2060
反应条件
sodium amide
1.) liquid ammonia, 5 min, 2.) liquid ammonia, 15 min; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Razzuk, Aziz; Biehl, Edward R.
Journal of Organic Chemistry, 1987 , vol. 52, # 12 p. 2619 - 2622
参考文献
Abbott Labor.
Patent: US2500714 , 1944 ;
反应条件
ammonium hydroxide; nickel in ethanol
T=40 - 50°C; 48 h;
参考文献
Langlois, Michel; Bremont, Beatrice; Shen, Shuren; Poncet, Annie; Andrieux, Jean; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 12 p. 2050 - 2060
反应条件
sulfuric acid
18 h; Heating; Yields of byproduct given;
参考文献
Dijkstra, Pieter J.; Skowronska-Ptasinska, Maria; Reinhoudt, David N.; Hertog, Herman J. den; Eerden, Johan van; et al.
Journal of Organic Chemistry, 1987 , vol. 52, # 22 p. 4913 - 4921
