2-氯甲基-1-甲氧基-4-甲基苯合成路线 （共 18 条）
反应条件
1: sodium acetate / 100 °C 2: aq.-ethanolic KOH 3: aqueous permanganate solution View Scheme
参考文献
Quelet et al.
Bulletin de la Societe Chimique de France, 1937 , vol. <5> 4, p. 1092,1095
反应条件
ethanol; platinum Hydrogenolyse;
参考文献
Vavon; Bolle; Calin
Bulletin de la Societe Chimique de France, 1939 , vol. <5> 6, p. 1025,1033
参考文献
Vavon; Bolle; Calin
Bulletin de la Societe Chimique de France, 1939 , vol. <5> 6, p. 1025,1033
反应条件
hydrogenchloride in benzene
T=25°C; 4 h;
参考文献
Keana, John F. W.; Cuomo, John; Lex, Laszlo; Seyedrezai, Seyed E.
Journal of Organic Chemistry, 1983 , vol. 48, # 16 p. 2647 - 2654
反应条件
pyridine; thionyl chloride in toluene
0 deg C to r.t.;
参考文献
Trillat, Anne-Cecile; Mathe-Allainmat, Monique; Bremont, Beatrice; Malagie, Isabelle; Jacquot, Christian; Gardier, Alain M.; Langlois, Michel
European Journal of Medicinal Chemistry, 1998 , vol. 33, # 6 p. 437 - 444
反应条件
1: 87 percent / LiAlH4 / tetrahydrofuran / 20 h / Heating
2: 69 percent / thionyl chloride, pyridine / toluene / 24 h / Ambient temperature
View Scheme
参考文献
Langlois, Michel; Bremont, Beatrice; Shen, Shuren; Poncet, Annie; Andrieux, Jean; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 12 p. 2050 - 2060
反应条件
1: 1.) Mg; 2.) Cu(OAc)2*H2O, O2 / 1.) THF; 2.) MeOH, NH4OH conc.
2: 78 percent / 37percent hydrochloric acid/HCl / benzene / 4 h / 25 °C
View Scheme
参考文献
Keana, John F. W.; Cuomo, John; Lex, Laszlo; Seyedrezai, Seyed E.
Journal of Organic Chemistry, 1983 , vol. 48, # 16 p. 2647 - 2654
反应条件
hydrogenchloride; zinc(II) chloride; Petroleum ether
T=10 - 15°C;
参考文献
Quelet
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1934 , vol. 198, p. 102
反应条件
1: platinum; ethanol / Hydrogenolyse
2: glacial acetic acid
View Scheme
参考文献
Vavon; Bolle; Calin
Bulletin de la Societe Chimique de France, 1939 , vol. <5> 6, p. 1025,1033
参考文献
Vavon; Bolle; Calin
Bulletin de la Societe Chimique de France, 1939 , vol. <5> 6, p. 1025,1033
