3,3-二甲基-2-亚甲基丁醛合成路线 （共 8 条）
反应条件
pyrrolidine; propionic acid in water; isopropyl alcohol
T=45°C; 4 h;
参考文献
Erkkilae, Anniina; Pihko, Petri M.
Journal of Organic Chemistry, 2006 , vol. 71, # 6 p. 2538 - 2541
反应条件
1: pyridinium chlorochromate / dichloromethane / 3.5 h / 0 - 20 °C / Inert atmosphere
2: pyrrolidine; propionic acid / water; isopropyl alcohol / 45 °C
View Scheme
参考文献
Logan, Angus W.J.; Parker, Jeremy S.; Hallside, Michal S.; Burton, Jonathan W.
Organic Letters, 2012 , vol. 14, # 12 p. 2940 - 2943
反应条件
1: aq. HCl / ethanol
2: H2O, Me2NH*HCl / 24 h / 70 °C
View Scheme
参考文献
Fujii; Hiraga; Yoshifuji; et al.
Chemical and Pharmaceutical Bulletin, 1978 , vol. 26, # 10 p. 3233 - 3237
反应条件
1: KOtBu / dimethylsulfoxide
2: aq. HCl / ethanol
3: H2O, Me2NH*HCl / 24 h / 70 °C
View Scheme
参考文献
Fujii; Hiraga; Yoshifuji; et al.
Chemical and Pharmaceutical Bulletin, 1978 , vol. 26, # 10 p. 3233 - 3237
反应条件
1: Br2, Ph3P
2: (i) Mg, ether, (ii) /BRN= 605384/, (iii) aq. H2SO4
3: H2O, Me2NH*HCl / 24 h / 70 °C
View Scheme
参考文献
Fujii; Hiraga; Yoshifuji; et al.
Chemical and Pharmaceutical Bulletin, 1978 , vol. 26, # 10 p. 3233 - 3237
反应条件
1: (i) Mg, ether, (ii) /BRN= 605384/, (iii) aq. H2SO4
2: H2O, Me2NH*HCl / 24 h / 70 °C
View Scheme
参考文献
Fujii; Hiraga; Yoshifuji; et al.
Chemical and Pharmaceutical Bulletin, 1978 , vol. 26, # 10 p. 3233 - 3237
反应条件
ethanol; palladium
Hydrogenation;
参考文献
Green; Hickinbottom
Journal of the Chemical Society, 1957 , p. 3270,3272
反应条件
1: sodium tetrahydroborate / diethyl ether; methanol / 0 - 20 °C / |Inert atmosphere
2: phosphorus tribromide / diethyl ether / 0 - 20 °C / |Inert atmosphere
View Scheme
参考文献
Ganguly, Ashit K.; Alluri, Sesha S.; Wang, Chih-Hung; Antropow, Alyssa; White, Alex; Caroccia, Danielle; Biswas, Dipshikha; Kang, Eunhee; Zhang, Li-Kang; Carroll, Steven S.; Burlein, Christine; Fay, John; Orth, Peter; Strickland, Corey
Tetrahedron, 2014 , vol. 70, # 18 p. 2894 - 2904
