1-[4-(三氟甲基)苯基]丙醇合成路线 （共 10 条）
反应条件
1: With (2R,3S,3aS,4aR,6R,8aS)-2-isopropyl-6,9,9-trimethyl-3-phenyldecahydro-4aH-pyrrolo[2,1-b][1,3]benzoxazin-3-ol in hexane; toluene T=20°C; Inert atmosphere; 2: With ammonium chloride in hexane; water; toluene optical yield given as percent eeenantioselective reaction;
参考文献
Shen, Bin; Huang, Huayin; Bian, Guangling; Zong, Hua; Song, Ling
Chirality, 2013 , vol. 25, # 9 p. 561 - 566
反应条件
dimethylsulfide borane complex; (S)-3,3-diphenyl-1-methyltetrahydro-1H,3H-pyrrolo[1,2-c][1,3,2]oxazaborol in tetrahydrofuran T=0°C; 0.5 h;
参考文献
Schering Corporation
Patent: US6391865 B1, 2002 ;
Location in patent: Page column 105 ;
US 6391865 B1
反应条件
1: triethylaluminum With 1,4-diaza-bicyclo[2.2.2]octane in tetrahydrofuran 2: 4-trifluoromethyl-benzaldehyde With [(R)-1,1'-binaphthyl-2,2'-diyldioxy]{bis[(S)-(1-phenylethyl)]amino}phosphine; bis(acetylacetonate)nickel(II) in tetrahydrofuran T=5°C; 1 h; Title compound not separated from byproducts;
参考文献
Angewandte Chemie - International Edition, , vol. 44, # 15 p. 2232 - 2234
反应条件
4-methyl-N-{[(1S,2S)-2-(pyrrolidin-1-yl)cyclohexyl]methyl}benzenesulfonamide in hexane T=0°C; 24 h; Inert atmosphere; optical yield given as percent eeenantioselective reaction;
参考文献
Hirose, Takuji; Sugawara, Kazuyuki; Kodama, Koichi
Journal of Organic Chemistry, 2011 , vol. 76, # 13 p. 5413 - 5428
反应条件
titanium(IV) isopropylate; DPP-H8-BINOL in tetrahydrofuran T=66°C; 2 h; Inert atmosphere; optical yield given as percent eeenantioselective reaction;
参考文献
Ukon, Takahiro; Harada, Toshiro
European Journal of Organic Chemistry, 2008 , # 26 p. 4405 - 4407
反应条件
Title compound not separated from byproducts.;
参考文献
Journal of the American Chemical Society, , vol. 123, # 22 p. 5378 - 5379
反应条件
(S)-12-(hydroxymethyl)-14-methyl-1(5,8)-quinolina-4(1,4)-benzenacyclohexaphane in toluene T=20°C; 5 h; Title compound not separated from byproducts;
参考文献
Ruzziconi, Renzo; Piermatti, Oriana; Ricci, Giacomo; Vinci, Daniele
Synlett, 2002 , # 5 p. 747 - 750
反应条件
chromium(VI) oxide; sulfuric acid
参考文献
Engler, Thomas A.; Combrink, Keith D.; Ray, James E.
Synthetic Communications, 1989 , vol. 19, # 9-10 p. 1735 - 1744
反应条件
in diethyl ether; dichloromethane
参考文献
J. URIACH and CIA. S.A.
Patent: EP612734 A1, 1994 ;
反应条件
1: CrO3; H2SO4 / acetone; H2O / 10 °C
2: 48percent HBr; Br2 / CH2Cl2; H2O / 35 °C
View Scheme
参考文献
Bartroli; Turmo; Alguero; Boncompte; Vericat; Garcia-Rafanell; Forn
Journal of Medicinal Chemistry, 1995 , vol. 38, # 20 p. 3918 - 3932
