5-溴-1-(4-氟苯基)-酞内酯合成路线 （共 12 条）
反应条件
in N,N-dimethyl-formamide 6 h; Heating;
参考文献
Jin, Chunyang; Boldt, Karl G.; Rehder, Kenneth S.; Brine, George A.
Synthetic Communications, 2007 , vol. 37, # 6 p. 901 - 908
反应条件
in N,N-dimethyl-formamide 4 h; Reflux;
参考文献
Reddy, M. Pulla; Bhujanga Rao; Usharani; Dubey
Asian Journal of Chemistry, 2011 , vol. 23, # 4 p. 1829 - 1832
反应条件
1: 5-bromo-1-(4-fluorophenyl)phthalan With sodium hydride; dimethyl sulfoxide in paraffin oil (nujol) T=20 - 25°C; 2.25 - 3.33333 h; 2: 1-dimethylamino-3-chloropropane in dimethyl sulfoxide; toluene T=25 - 30°C; 0.5 h; 3: With methanol in dimethyl sulfoxide; toluene
参考文献
NATCO PHARMA LIMITED
Patent: WO2004/16602 A1, 2004 ;
Location in patent: Page 19-20 ;
反应条件
1.1: N,N-dimethyl-formamide / 4 h / Reflux 2.1: sodium hydride / dimethyl sulfoxide; paraffin oil / 0.17 h / 20 °C / Inert atmosphere 2.2: 0.83 h / 40 °C View Scheme
参考文献
Reddy, M. Pulla; Bhujanga Rao; Usharani; Dubey
Asian Journal of Chemistry, 2011 , vol. 23, # 4 p. 1829 - 1832
反应条件
1.1: 2.44 g / dimethylformamide / 6 h / Heating 2.1: sodium methylsulfinylmethide / dimethylsulfoxide; various solvent(s) / 0.33 h 2.2: dimethylsulfoxide; various solvent(s) / 1 h / 20 °C 3.1: 4.11 g / aq. HCl View Scheme
参考文献
Jin, Chunyang; Boldt, Karl G.; Rehder, Kenneth S.; Brine, George A.
Synthetic Communications, 2007 , vol. 37, # 6 p. 901 - 908
反应条件
toluene-4-sulfonic acid in toluene
Heating / reflux;
参考文献
NATCO PHARMA LIMITED
Patent: WO2004/16602 A1, 2004 ;
Location in patent: Page 15 ;
反应条件
1: magnesium; 1-bromo-4-fluorobenzene With iodine in tetrahydrofuran
2: 5-bromo-3H-isobenzofuran-1-one in tetrahydrofuran; toluene
T=-6 - -2°C;
3: With sodium tetrahydroborate; water; ammonium chloride; toluene-4-sulfonic acid
more than 3 stages;
参考文献
JUBILANT ORGANOSYS LTD.
Patent: WO2004/20425 A1, 2004 ;
Location in patent: Page 13 ;
反应条件
in tetrahydrofuran; chloroform
参考文献
JUBILANT ORGANOSYS LTD.
Patent: WO2004/20425 A1, 2004 ;
Location in patent: Page 11 ;
反应条件
1: acetic acid / 0.25 h / 20 °C
2: lead(IV) tetraacetate / tetrahydrofuran / 4 h / 0 °C / |Inert atmosphere
3: sodium tetrahydroborate; pyridine / methanol / 5 h / 20 °C
4: toluene-4-sulfonic acid / toluene / 3 h / |Reflux
View Scheme
参考文献
Wang, Peng; Zhang, Rui; Cai, Jin; Chen, Jun-Qing; Ji, Min
Chinese Chemical Letters, 2014 , vol. 25, # 4 p. 549 - 552
反应条件
1: lead(IV) tetraacetate / tetrahydrofuran / 4 h / 0 °C / |Inert atmosphere
2: sodium tetrahydroborate; pyridine / methanol / 5 h / 20 °C
3: toluene-4-sulfonic acid / toluene / 3 h / |Reflux
View Scheme
参考文献
Wang, Peng; Zhang, Rui; Cai, Jin; Chen, Jun-Qing; Ji, Min
Chinese Chemical Letters, 2014 , vol. 25, # 4 p. 549 - 552
