1: 2-bromo-5-methoxy benzoic acid With borane in tetrahydrofuran
2: benzyl bromide With tetra-(n-butyl)ammonium iodide; sodium hydride
3: vinylboronic acid dibutyl ester With sodium ethanolate; tetrakis(triphenylphosphine) palladium(0)
Suzuki reaction; Title compound not separated from byproducts;
1: 3-bromo-pyridine With isopropylmagnesium chloride in tetrahydrofuran
T=20°C; 1 h;
2: vinylboronic acid dibutyl ester in tetrahydrofuran
T=20°C; 18 h;
3: With hydrogenchloride in tetrahydrofuran; water
pH=7;
参考文献
Bellinger-Kawahara, Carolyn; Maples, Kirk R.; Plattner, Jacob J.
Patent: US2006/19927 A1, 2006 ;
Location in patent: Page/Page column 15 ;