1-(3-甲氧基苯基)-2-苯基乙酮合成路线 （共 27 条）
反应条件
1: 1.) NaH / 1.) DMF, 2.) DMF 2: 72 percent / 48percent aq. HBr, acetic acid / 9 h / Heating 3: 98percent H2SO4 / 12 h / Ambient temperature 4: 1.) C2H5MgBr, 3.) HCl View Scheme
参考文献
Ruenitz, Peter C.; Bagley, Jerome R.; Mokler, Corwin M.
Journal of Medicinal Chemistry, 1982 , vol. 25, # 9 p. 1056 - 1060
反应条件
ammonium chloride; bipyridine-cyclopalladated ferrocenylimine complex in water
T=100°C; 24 h;
参考文献
Yu, Ajuan; Li, Jingya; Cui, Mengjun; Wu, Yangjie
Synlett, 2007 , # 19 p. 3063 - 3067
反应条件
palladium diacetate; 1,4-di(diphenylphosphino)-butane in tetrahydrofuran
T=90°C; P=1500.15 Torr; 1 h; Sealed tubeMicrowave irradiation; chemoselective reaction;
参考文献
Motwani, Hitesh V.; Larhed, Mats
European Journal of Organic Chemistry, 2013 , # 22 p. 4729 - 4733
反应条件
trans-di(μ-acetato)bis[o-(di-o-tolylphosphino)benzyl]dipalladium(II); 1,8-diazabicyclo[5.4.0]undec-7-ene; [(t-Bu)3PH]BF4 in tetrahydrofuran
T=120°C; P=2250.23 Torr; 0.5 h; Microwave irradiationSealed tube; chemoselective reaction;
参考文献
Motwani, Hitesh V.; Larhed, Mats
European Journal of Organic Chemistry, 2013 , # 22 p. 4729 - 4733
反应条件
1: 3-methoxybromobenzene With n-butyllithium in tetrahydrofuran; hexane
T=-78°C; 0.333333 h;
2: N-methoxy-N-methyl-2-phenylacetamide in tetrahydrofuran; hexane
Further stages.;
参考文献
Moreno, Isabel; Tellitu, Imanol; Dominguez, Esther; SanMartin, Raul
European Journal of Organic Chemistry, 2002 , # 13 p. 2126 - 2135
反应条件
bis-triphenylphosphine-palladium(II) chloride; triethylamine in tetrahydrofuran
T=80°C; 3 h; Schlenk tubeInert atmosphere;
参考文献
Rao, Maddali L.N.; Giri, Somnath; Jadhav, Deepak N.
Tetrahedron Letters, 2009 , vol. 50, # 45 p. 6133 - 6138
反应条件
pyrrolidine; tetrabutylammomium bromide; palladium diacetate in N,N-dimethyl-formamide
T=100°C; 15 h; Molecular sieveInert atmosphere;
参考文献
Adak, Laksmikanta; Bhadra, Sukalyan; Ranu, Brindaban C.
Tetrahedron Letters, 2010 , vol. 51, # 29 p. 3811 - 3814
反应条件
tris-(dibenzylideneacetone)dipalladium(0); bis[2-(diphenylphosphino)phenyl] ether; sodium t-butanolate in tetrahydrofuran
T=70°C; Schlenk techniqueInert atmosphere;
参考文献
Mehta, Vaibhav P.; Garcia-Lopez, Jose-Antonio; Greaney, Michael F.
Angewandte Chemie - International Edition, 2014 , vol. 53, # 6 p. 1529 - 1533
Angew. Chem., 2014 , vol. 126, # 6 p. 1555 - 1559,5
反应条件
Ni(PCy3)2Cl2; sodium t-butanolate in N,N-dimethyl-formamide; toluene
T=100°C; Suzuki-Miyaura coupling; 0.666667 h; Inert atmosphere;
参考文献
Huang, Kun; Li, Gang; Huang, Wei-Ping; Yu, Da-Gang; Shi, Zhang-Jie
Chemical Communications, 2011 , vol. 47, # 25 p. 7224 - 7226
反应条件
potassium hydroxide in ethanol; water
Heating;
参考文献
McEwen, William E.; Grossi, Anthony V.; MacDonald, Russell J.; Stamegna, Andrew P.
Journal of Organic Chemistry, 1980 , vol. 45, # 7 p. 1301 - 1308
