顺式-4-羟基-L-脯氨酸合成路线 （共 45 条）
反应条件
1: dioxane; diethyl ether 2: pyridine 3: aqueous methanol. NaOH / 0 °C 4: aqueous NaOH 5: aqueous HCl View Scheme
参考文献
Journal of the Chemical Society, , p. 431
反应条件
1: pyridine 2: aqueous methanol. NaOH / 0 °C 3: aqueous NaOH 4: aqueous HCl View Scheme
参考文献
Journal of the Chemical Society, , p. 431
反应条件
1: aqueous NaOH 2: aqueous HCl View Scheme
参考文献
Journal of the Chemical Society, , p. 431
反应条件
1: aqueous methanol. NaOH / 0 °C 2: aqueous NaOH 3: aqueous HCl View Scheme
参考文献
Journal of the Chemical Society, , p. 431
反应条件
2: 1) DAST, 2) RuO4 3: 1) HCl, 2) Ag2O View Scheme
参考文献
Hudlicky, Milos
Journal of Fluorine Chemistry, 1991 , vol. 54, # 1-3 p. 195
反应条件
sodium carbonate in 1,4-dioxane; water T=0 - 20°C;
参考文献
Taylor, Carol M.; Hardre, Renaud; Edwards, Patrick J. B.
Journal of Organic Chemistry, 2005 , vol. 70, # 4 p. 1306 - 1315
反应条件
sodium hydroxide in tetrahydrofuran; water pH=9 - 10;
参考文献
GILEAD SCIENCES, INC.; DESAI, Manoj, C.; HUI, Hon Chung; LIU, Hongtao; SUN, Jianyu; XU, Lianhong
Patent: WO2012/88156 A1, 2012 ;
Location in patent: Page/Page column 60-61 ;
WO 2012/088156 A1
反应条件
1: dimethylsulfoxide / 20 - 50 °C 2: 38 percent / diethylaminosulfur trifluoride / CH2Cl2 / 20 h / 0 - 20 °C 3: 22 percent / water / propan-2-ol / 48 h / 20 °C View Scheme
参考文献
Hamacher, Kurt
Journal of Labelled Compounds and Radiopharmaceuticals, 1999 , vol. 42, # 12 p. 1135 - 1144
反应条件
sodium hydrogencarbonate 3 h; from 0 deg C to r.t.;
参考文献
Brown, Allan G.; Moss, Stephen F.; Southgate, Robert
Tetrahedron Letters, 1994 , vol. 35, # 3 p. 451 - 454
反应条件
ethanol; sodium hydrogencarbonate
参考文献
Rao; Sober
Journal of the American Chemical Society, 1954 , vol. 76, p. 1328,1330
