6-苯基-2,2'-联吡啶合成路线 （共 9 条）
反应条件
1: 2-bromo-pyridine With n-butyllithium in diethyl ether; hexane
T=-78 - 0°C; 0.5 h; Inert atmosphere;
2: 2-bromo-6-phenyl-pyridine With tetrakis(triphenylphosphine) palladium(0); zinc(II) chloride in tetrahydrofuran; diethyl ether; hexane
T=20°C; 1 h; Inert atmosphereReflux;
参考文献
Vezzu, Dileep A.K.; Lu, Qun; Chen, Yan-Hua; Huo, Shouquan
Journal of Inorganic Biochemistry, 2014 , vol. 134, p. 49 - 56
反应条件
in diethyl ether; cyclohexane
T=5 - 20°C; 2.25 h;
参考文献
Takasago International Corporation
Patent: EP1683804 A2, 2006 ;
Location in patent: Page/Page column 27 ;
反应条件
[Ni0(1,5-cyclooctadiene)2]; tri-cyclo-hexyl-phosphine in toluene
T=130°C; 20 h;
参考文献
Tobisu, Mamoru; Hyodo, Isao; Chatani, Naoto
Journal of the American Chemical Society, 2009 , vol. 131, # 34 p. 12070 - 12071
反应条件
tetrafluoroboric acid; hydrogen; nickel in ethanol
P=760 Torr; 16 h; Ambient temperature;
参考文献
Kanemasa Asai; Tanaka
Bulletin of the Chemical Society of Japan, 1991 , vol. 64, # 2 p. 375 - 380
反应条件
1: 84 percent / Et3N / diethyl ether / Ambient temperature
2: 1) (COCl)2, DMSO, 3) Et3N
3: 13 percent / H2, 42percent aq. HBF3 / Raney Ni / ethanol / 16 h / 760 Torr / Ambient temperature
View Scheme
参考文献
Kanemasa Asai; Tanaka
Bulletin of the Chemical Society of Japan, 1991 , vol. 64, # 2 p. 375 - 380
反应条件
1: 1) (COCl)2, DMSO, 3) Et3N
2: 13 percent / H2, 42percent aq. HBF3 / Raney Ni / ethanol / 16 h / 760 Torr / Ambient temperature
View Scheme
参考文献
Kanemasa Asai; Tanaka
Bulletin of the Chemical Society of Japan, 1991 , vol. 64, # 2 p. 375 - 380
反应条件
1: 84 percent / Et3N / diethyl ether / Ambient temperature
2: 1) (COCl)2, DMSO, 3) Et3N
3: 13 percent / H2, 42percent aq. HBF3 / Raney Ni / ethanol / 16 h / 760 Torr / Ambient temperature
View Scheme
参考文献
Kanemasa Asai; Tanaka
Bulletin of the Chemical Society of Japan, 1991 , vol. 64, # 2 p. 375 - 380
反应条件
ammonium acetate in acetic acid
1.) 115 deg C, 10 min 2.) 115 deg C, 5 h;
参考文献
Constable, Edwin C.; Henney, Roland P. G.; Leese, Troy A.; Tocher, Derek A.
Journal of the Chemical Society, Dalton Transactions: Inorganic Chemistry (1972-1999), 1990 , # 2 p. 443 - 449
反应条件
diethyl ether; phenyllithium
Behandeln des Reaktionsprodukts mit Nitrobenzol;
参考文献
Knott; Breckenridge
Canadian Journal of Chemistry, 1954 , vol. 32, p. 512,513
