2',4'-二氯苯甲酰基乙酸乙酯合成路线 （共 10 条）
反应条件
sodium hydride T=80°C; 1 h;
参考文献
WO2005/108412 A1, ;
Page/Page column 41-42 ;
反应条件
sulfuryl dichloride in chloroform
参考文献
Reuman, Michael; Daum, Sol J.; Singh, Baldev; Wentland, Mark P.; Perni, Robert B.; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 14 p. 2531 - 2540
反应条件
1: polystyrene-supported α-seleno acetate, loading 1.64 mmol/g (COOH) With lithium diisopropyl amide in tetrahydrofuran T=-78°C; 0.5 h; 2: 2,4-di-(chloro)-benzaldehyde in tetrahydrofuran T=-78 - 20°C; 2.5 h; 3: With dihydrogen peroxide in tetrahydrofuran T=20°C;
参考文献
Synlett, , # 10 p. 1547 - 1548
反应条件
1: Mg / ethanol; CCl4; diethyl ether / 2 h / 60 °C 2: 1.) KOH, 2.) NH4Cl, 30 percent NH3 / 1.) EtOH, RT, 15 min, 2.) H2O, 2.5 h View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 30, # 9 p. 721 - 726
反应条件
1.1: LDA / tetrahydrofuran / 2 h / -78 °C 1.2: 76 percent / tetrahydrofuran / 2 h / -78 - 20 °C 2.1: 87 percent / aq. H2O2 / tetrahydrofuran / 3 h / 20 - 50 °C View Scheme
参考文献
Journal of Chemical Research, , # 3 p. 160 - 161
反应条件
potassium hydroxide; ammonium hydroxide; ammonium chloride 1.) EtOH, RT, 15 min, 2.) H2O, 2.5 h; Yield given;
参考文献
European Journal of Medicinal Chemistry, , vol. 30, # 9 p. 721 - 726
参考文献
Monsanto Company
Patent: US4308391 A1, 1981 ;
反应条件
hydroxylamine hydrochloride; potassium carbonate in ethanol T=40°C;
参考文献
Bayer CropScience AG
Patent: US2012/100989 A1, 2012 ;
Location in patent: Page/Page column 22 ;
反应条件
1: 1.) NaOEt / 1.) EtOH, reflux, 30 min, 2.) EtOH, reflux, 7 h 2: 47percent HBr / Heating View Scheme
参考文献
Cignarella, G.; Barlocco, D.; Pocar, D.; Clerici, F.; Curzu, M. M.; et al.
European Journal of Medicinal Chemistry, 1995 , vol. 30, # 9 p. 721 - 726
