2-(3-氟苯基)乙酸乙酯合成路线 （共 7 条）
反应条件
thionyl chloride
T=0 - 20°C; 2 h;
参考文献
DAIICHI PHARMACEUTICAL CO., LTD.
Patent: EP1479681 A1, 2004 ;
Location in patent: Page 82 ;
反应条件
1: aqueous sulfuric acid
2: sulfuric acid
View Scheme
参考文献
Corse et al.
Journal of the American Chemical Society, 1948 , vol. 70, p. 2837,2842
反应条件
triethylamine tris(hydrogen fluoride) in sulfolane
T=50°C; electrolysis; Further byproducts given. Yields of byproduct given;
参考文献
Laurent, Eliane; Marquet, Bernard; Tardivel, Robert
Journal of Fluorine Chemistry, 1990 , vol. 49, # 1 p. 115 - 126
反应条件
sodium in benzene
24 h; Heating;
参考文献
Shandala, Mowafak Y.; Al-Khashab, Abdul-Ilah Y.; Afzal, M.; Ahmad, Shakir S.
Journal of Heterocyclic Chemistry, 1980 , vol. 17, p. 1605 - 1607
反应条件
sodium in benzene
24 h; Heating;
参考文献
Shandala, Mowafak Y.; Al-Khashab, Abdul-Ilah Y.; Afzal, M.; Ahmad, Shakir S.
Journal of Heterocyclic Chemistry, 1980 , vol. 17, p. 1605 - 1607
反应条件
sodium in benzene
24 h; Heating;
参考文献
Shandala, Mowafak Y.; Al-Khashab, Abdul-Ilah Y.; Afzal, M.; Ahmad, Shakir S.
Journal of Heterocyclic Chemistry, 1980 , vol. 17, p. 1605 - 1607
反应条件
1: 70 percent / NBS, 48percent aq. HBr / CCl4 / Heating
2: 47 percent / NaOEt / diethyl ether / 24 h / Ambient temperature
3: 21 percent / KOH / ethanol; H2O / 6 h / Heating
4: 50 percent / urea / xylene / Heating
5: 33 percent / sodium bis(2-methoxyethoxy)aluminum hydride / benzene / 2 h / Heating
View Scheme
参考文献
Epstein, Joseph W.; Brabander, Herbert J.; Fanshawe, William J.; Hofmann, Corris M.; McKenzie, Thomas C.; et al.
Journal of Medicinal Chemistry, 1981 , vol. 24, # 5 p. 481 - 490
