4-氨基-1,2,4-三氮唑合成路线 （共 68 条）
反应条件
acetic acid T=170°C; 4 h;
参考文献
Marwaha, Alka; White, John; El-mazouni, Farah; Creason, Sharon A; Kokkonda, Sreekanth; Buckner, Frederick S.; Charman, Susan A.; Phillips, Margaret A.; Rathod, Pradipsinh K.
Journal of Medicinal Chemistry, 2012 , vol. 55, # 17 p. 7425 - 7436
反应条件
1,4-diaza-bicyclo[2.2.2]octane in chloroform
参考文献
Konstantinova, Lidia S.; Lysov, Kirill A.; Rakitin, Oleg A.
Synthesis (Germany), 2013 , vol. 45, # 5 art. no. SS-2012-Z0928-OP, p. 655 - 658
参考文献
Rachlin, Schneur; Bramm, E.; Ahnfelt-Ronne, I.; Arrigoni-Martelli, E.
Journal of Medicinal Chemistry, 1980 , vol. 23, # 1 p. 13 - 20
反应条件
NOBF4 in acetonitrile
T=25°C;
参考文献
Abramovitch; Beckert; Gibson Jr.; Belcher; Hundt; Sierra; Olivella; Pennington; Sole
Journal of Organic Chemistry, 2001 , vol. 66, # 4 p. 1242 - 1251
反应条件
in acetonitrile
T=50°C;
参考文献
Drake, Greg W.; Hawkins, Tommy; Tollison, Kerri
Patent: US7745635 B1, 2010 ;
Location in patent: Page/Page column 6 ;
反应条件
in water
T=100°C; P=5.00075 Torr; 2 h; Heating / reflux;
参考文献
CLARIANT (FRANCE)
Patent: WO2004/13081 A1, 2004 ;
Location in patent: Page 45 ;
反应条件
hydrogenchloride; sodium nitrite
1.) i-PrOH; Multistep reaction;
参考文献
Kolczewski, Sabine; Adam, Geo; Stadler, Heinz; Mutel, Vincent; Wichmann, Juergen; Woltering, Thomas
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 15 p. 2173 - 2176
反应条件
hydrogenchloride; sodium nitrite
2.) H2O; Yield given. Multistep reaction;
参考文献
Becker, H. G. O.; Hoffmann, Gerda; Gwan, Kim Mun; Knuepfer, L.
Journal fuer Praktische Chemie (Leipzig), 1988 , vol. 330, # 3 p. 325 - 337
反应条件
in N,N-dimethyl-formamide
T=70 - 75°C; Alkylation; 3 h;
参考文献
Gromova; Barmin; Kolesnikova; Shlyapochnikov; Mel'nikov
Russian Journal of Organic Chemistry, 1996 , vol. 32, # 8 p. 1190 - 1193
反应条件
pyridine; triethylamine in chloroform
5 h; Heating;
参考文献
Abramovitch; Beckert; Gibson Jr.; Belcher; Hundt; Sierra; Olivella; Pennington; Sole
Journal of Organic Chemistry, 2001 , vol. 66, # 4 p. 1242 - 1251
