反应条件
1: 2-(Methylthio)-3,4-dihydropyrimidin-4-one With triethylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate in 1,4-dioxane
T=20°C; 2 h; Inert atmosphereSealed tube;
2: 3,4,5-trimethoxyphenylboronic acid With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate in 1,4-dioxane; water
T=100°C; Suzuki coupling; 4 h; Inert atmosphereSealed tube; chemoselective reaction;
参考文献
Cernova, Miroslava; Pohl, Radek; Klepetarova, Blanka; Hocek, Michal
Synlett, 2012 , vol. 23, # 9 p. 1305 - 1308