5,5-二甲基-1-苯己烷-1,4-二酮合成路线 （共 20 条）
反应条件
zinc(II) chloride in tetrahydrofuran
T=40°C; Alkylation; 3 h;
参考文献
Yasuda, Makoto; Tsuji, Shoki; Shigeyoshi, Yusuke; Baba, Akio
Journal of the American Chemical Society, 2002 , vol. 124, # 25 p. 7440 - 7447
反应条件
tetrakis(triphenylphosphine) palladium(0) in 1,4-dioxane
Heating;
参考文献
Echavarren, Antonio M.; Perez, Marta; Castano, Ana M.; Cuerva, Juan M.
Journal of Organic Chemistry, 1994 , vol. 59, # 15 p. 4179 - 4185
反应条件
1: 4,4-dimethyl-1-[(dichlorobutyl)stannyl]-3-pentanone With n-butyllithium in tetrahydrofuran; hexane
T=-78 - 0°C; 0.5 h;
2: With copper (I) cyanide in tetrahydrofuran
T=-78 - 0°C; 0.5 h;
3: benzoyl chloride T=-78°C; 1 h;
参考文献
Ryu, Ilhyong; Ikebe, Masanobu; Sonoda, Noboru; Yamato, Shin-Ya; Yamamura, Go-Hei; Komatsu, Mitsuo
Tetrahedron Letters, 2002 , vol. 43, # 7 p. 1257 - 1259
反应条件
1: diiodomethane With diethylzinc; trifluoroacetic acid in dichloromethane
T=0°C; 0.5 h;
2: 4,4-dimethyl-1-phenylpentane-1,3-dione in dichloromethane
T=20°C; 5 h;
参考文献
Xue, Song; Li, Le-Zhen; Liu, Yong-Kang; Guo, Qing-Xiang
Journal of Organic Chemistry, 2006 , vol. 71, # 1 p. 215 - 218
反应条件
ammonium cerium(IV) nitrate in acetonitrile
0.5 h; Ambient temperature;
参考文献
Narasaka, Koichi; Okauchi, Tatsuo; Tanaka, Ken; Murakami, Masaharu
Chemistry Letters, 1992 , # 10 p. 2099 - 2102
反应条件
1: Me3COLi / hexamethylphosphoric acid triamide
2: 37 percent / hexamethylphosphoric acid triamide / 4 h / Irradiation
View Scheme
参考文献
Russell, Glen A.; Kulkarni, Shekhar V.; Khanna, Rajive K.
Journal of Organic Chemistry, 1990 , vol. 55, # 3 p. 1080 - 1086
反应条件
in N,N,N',N',N'',N''-hexamethylphosphoric triamide
4 h; Irradiation;
参考文献
Russell, Glen A.; Kulkarni, Shekhar V.; Khanna, Rajive K.
Journal of Organic Chemistry, 1990 , vol. 55, # 3 p. 1080 - 1086
反应条件
1.1: n-butyllithium / tetrahydrofuran / -78 °C
1.2: 74 percent / tetrahydrofuran / -78 - 20 °C
2.1: 20 percent Spectr. / [Ru(PPh3)3(CO)H2]; Xantphos; propanoic acid / toluene / 24 h / 110 °C
View Scheme
参考文献
Pridmore, Simon J.; Slatford, Paul A.; Williams, Jonathan M.J.
Tetrahedron Letters, 2007 , vol. 48, # 29 p. 5111 - 5114
反应条件
1.1: n-butyllithium / tetrahydrofuran / -78 °C
1.2: 74 percent / tetrahydrofuran / -78 - 20 °C
2.1: 20 percent Spectr. / [Ru(PPh3)3(CO)H2]; Xantphos; propanoic acid / toluene / 24 h / 110 °C
View Scheme
参考文献
Pridmore, Simon J.; Slatford, Paul A.; Williams, Jonathan M.J.
Tetrahedron Letters, 2007 , vol. 48, # 29 p. 5111 - 5114
反应条件
water; sodium chloride in dimethyl sulfoxide
20 h; Heating; Yield given;
参考文献
Smith, Jonathan O.; Mandal, Braja K.
Journal of Heterocyclic Chemistry, 1997 , vol. 34, # 5 p. 1441 - 1446
